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Suppression of ITGB4 Gene Expression in PC-3 Cells with Short Interfering RNA Induces Changes in the Expression of β-Integrins Associated with RGD-Receptors

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Bulletin of Experimental Biology and Medicine Aims and scope

An Erratum to this article was published on 29 October 2015

An Erratum to this article was published on 01 September 2015

We studied the effect of transfection of PC-3 prostate cancer cells with a plasmid encoding shRNA complimentary to a fragment of integrin β4 (ITGB4). The results attest to considerable changes in the transcriptome of transfected cells. For instance, compensatory changes in the expression of integrin family genes were found.

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Authors and Affiliations

  1. BioClinicum Research and Technical Centre, Moscow, Russia

    E. N. Knyazev, T. R. Samatov & M. Yu. Shkurnikov

  2. Federal Medical Research Center, Ministry of Health of the Russian Federation, Moscow, Russia

    K. M. Nyushko, B. Ya. Alekseev & M. Yu. Shkurnikov

Authors
  1. E. N. Knyazev
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  2. K. M. Nyushko
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  3. B. Ya. Alekseev
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  4. T. R. Samatov
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  5. M. Yu. Shkurnikov
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Corresponding author

Correspondence to M. Yu. Shkurnikov.

Additional information

Translated from Kletochnye Tekhnologii v Biologii i Meditsine, No. 2, pp. 85–89, April, 2015

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Knyazev, E.N., Nyushko, K.M., Alekseev, B.Y. et al. Suppression of ITGB4 Gene Expression in PC-3 Cells with Short Interfering RNA Induces Changes in the Expression of β-Integrins Associated with RGD-Receptors. Bull Exp Biol Med 159, 541–545 (2015). https://doi.org/10.1007/s10517-015-3011-9

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  • DOI: https://doi.org/10.1007/s10517-015-3011-9

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