Exposure of Mel Ibr human melanoma cells to chicken embryo extract resulted in the appearance of a subclone with morphological and growth characteristics similar to those of embryonic stem cells. The subclone differed from the parental line cells by a sharply reduced percentage of HLA-DR+ and CD54+ cells, a significantly elevated percentage of CD63+ cells, and appearance of CD133+ and Oct-4A+ cells. Hence, the subclone cells were characterized by the same features as stem tumor cells and could be responsible for further progress of tumor growth.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 159, No. 4, pp. 521-524, April, 2015
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Suraeva, N.M., Morozova, L.F., Samoilov, A.V. et al. Changes in the Morphological and Immunological Characteristics of Mel Ibr Melanoma Cells in Response to Chicken Embryo Extract. Bull Exp Biol Med 159, 520–523 (2015). https://doi.org/10.1007/s10517-015-3007-5
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DOI: https://doi.org/10.1007/s10517-015-3007-5