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Anti-Parkinsonian Activity of Hemantane on a Model of Hemiparkinsonian Syndrome in Rats

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Hemantane demonstrated a pronounced antiparkinsonian activity in the model of hemiparkinsonian syndrome provoked in rats by unilateral intracerebral injection of 6-hydroxydopamine, which was comparable to efficacy of levodopa in decreasing the duration of cataleptogenic state and the degree of akinesia of the contralesional forelimb assessed in the cylinder test. In the stepping test, hemantane exerted a long-term effect in contrast to levodopa, which diminished its beneficial action to the treatment day 21. In the swing test, the behavior normalized only by hemantane.

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Authors and Affiliations

  1. V. V. Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia

    E. A. Ivanova, I. G. Kapitsa, E. A. Val’dman & T. A. Voronina

Authors
  1. E. A. Ivanova
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  2. I. G. Kapitsa
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  3. E. A. Val’dman
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  4. T. A. Voronina
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Corresponding author

Correspondence to E. A. Ivanova.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 159, No. 3, pp. 362–365, March, 2015

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Ivanova, E.A., Kapitsa, I.G., Val’dman, E.A. et al. Anti-Parkinsonian Activity of Hemantane on a Model of Hemiparkinsonian Syndrome in Rats. Bull Exp Biol Med 159, 380–383 (2015). https://doi.org/10.1007/s10517-015-2968-8

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  • DOI: https://doi.org/10.1007/s10517-015-2968-8

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