Using rat model of experimental anxiety-depressive disorder caused by postnatal administration of methionyl-2(S)-cyanopyrrolidine, an inhibitor of dipeptidyl peptidase IV, we compared conditioned active avoidance response and memory retention in males and females. In experimental males and females, conditioning was impaired in comparison with the control. In experimental groups, females were worse learners than males, while in control groups, females were better learners than males. Memory retention in experimental animals did not differ from that in controls 24 h after learning. Two months after learning, control females demonstrated better retention than control males.
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N. A. Krupina, E. Yu. Kushnareva, N. N. Khlebnikova, et al., Zh. Vyssh. Nervn. Deyat., 59, No. 3, 360-372 (2009).
E. Yu. Kushnareva, N. A. Krupina, N. N. Khlebnikova, et al., Bull. Exp. Biol. Med., 151, No. 6, 675-679 (2011).
G. A. Nazarova, N. N. Zolotov, N. A. Krupina, et al., Eksp. Klin. Farmakol., 70, No. 6, 6-8 (2007).
G. A. Romanova, D. N. Silachev, F. M. Shakova, and Yu. N. Kvashennikova, Patogenez, Nos. 1-2, 99-102 (2007).
N. N. Khlebnikova, N. A. Krupina, and E. Yu. Kushnareva, Patol. Fiziol. Eksp. Ter., No. 4, 3-9 (2013).
C. Anacke, P. A. Zunszain, A. Cattaneo, et al., Molec. Psychiatry, 16, No. 7, 738-750 (2011).
J. M. Andreano and L. Cahill, Learn Mem., 16, No. 4, 248-266 (2009).
Y. Benjamini and Y. Hochberg , J. R. Statist. Soc. B, 57, No. 1, 289-300 (1995).
A. Brzezicka, Acta Neurobiol. Exp. (Wars.), 73, No. 3, 313-325 (2013).
S. Campbell and G. Macqueen, J. Psychiatry Neurosci., 29, No. 6, 417-426 (2004).
B. Czéh, T. Michaelis, T. Watanabe, et al., Proc. Natl Acad. Sci. USA, 98, No. 22, 12,796-12,801 (2001).
K. I. Erickson, D. L. Miller, and K. A. Roecklein, Neuroscientist, 18, No. 1, 82-97 (2012).
K. I. Erickson, M. W. Voss, R. S. Prakash, et al., Proc. Natl Acad. Sci. USA, 108, No. 7, 3017-3022 (2011).
Y. Lin, G. J. Ter Horst, and R. Wichmann, Cereb. Cortex, 19, No. 9, 1978-1989 (2009).
P. J. Lucassen, J. Pruessner, N. Sousa, et al., Acta Neuropathol., 127, No. 1, 109-135 (2014).
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 159, No. 3, pp. 348-352, March, 2015
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Khlebnikova, N.N., Krupina, N.A., Kushnareva, E.Y. et al. Differences in Active Avoidance Conditioning in Male and Female Rats with Experimental Anxiety-Depressive Disorder. Bull Exp Biol Med 159, 337–340 (2015). https://doi.org/10.1007/s10517-015-2956-z
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DOI: https://doi.org/10.1007/s10517-015-2956-z