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Changes in Oxygen Partial Pressure in the Vitreous Body and Arterial Blood of Rabbits Depending on Oxygen Concentration in Inspired Mixture

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We demonstrated that the vitreous body of one-month-old rabbits becomes a “reservoir” for storage and accumulation of oxygen after exposure to additional oxygenation of the organism (O2 concentrations in inspired gas mixture were 40, 60, 85, and 99%). The higher was O2 concentration in inspired mixture, the higher was oxygen saturation of the blood and vitreous body. O2 concentration of 40% was relatively safe for eye tissues. O2 concentration >60% induced oxygen accumulation in the vitreous body, which can be a provoking factor for the development of oxygen-induced pathologies.

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Authors and Affiliations

  1. Department of Ophthalmology, Faculty of Pediatrics, N. I. Pirogov Russian National Research Medical University, Moscow, Russia

    L. I. Amkhanitskaya & G. V. Nikolaeva

  2. Department of Clinical Laboratory Diagnostics, Faculty of Continuing Medical Education, N. I. Pirogov Russian National Research Medical University, Moscow, Russia

    N. A. Sokolova

Authors
  1. L. I. Amkhanitskaya
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  2. G. V. Nikolaeva
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  3. N. A. Sokolova
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Corresponding author

Correspondence to L. I. Amkhanitskaya.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 159, No. 3, pp. 308-310, March, 2015

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Amkhanitskaya, L.I., Nikolaeva, G.V. & Sokolova, N.A. Changes in Oxygen Partial Pressure in the Vitreous Body and Arterial Blood of Rabbits Depending on Oxygen Concentration in Inspired Mixture. Bull Exp Biol Med 159, 331–333 (2015). https://doi.org/10.1007/s10517-015-2954-1

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  • DOI: https://doi.org/10.1007/s10517-015-2954-1

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