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Factors of Th17 and Treg Lymphocyte Differentiation in Pulmonary Tuberculosis

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Bulletin of Experimental Biology and Medicine Aims and scope

In patients with infiltrative pulmonary tuberculosis, the increase in IL-6 secretion, the decrease in TGFβ production (in case of drug resistance of the causative agent), and unchanged level of IL-1β secretion by mononuclear leukocytes in vitro were associated with increased number of CD4+CD161+IL-17A+ Th17 lymphocytes in the peripheral blood. In patients with disseminated drug-resistant pulmonary tuberculosis, TGFβ hyperproduction promoted differentiation of CD4+CD25+FoxP3+ Treg lymphocytes with immunosuppressive activity.

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Authors and Affiliations

  1. Department of Pathophysiology, Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia

    T. E. Kononova, O. I. Urazova, V. V. Novitskii, Yu. V. Kolobovnikova, E. G. Churina & P. A. Zakharova

  2. National Research Tomsk State University, Tomsk, Russia

    V. V. Novitskii

Authors
  1. T. E. Kononova
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  2. O. I. Urazova
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  3. V. V. Novitskii
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  4. Yu. V. Kolobovnikova
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  5. E. G. Churina
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  6. P. A. Zakharova
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Corresponding author

Correspondence to T. E. Kononova.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 159, No. 2, pp. 158-161, February, 2015

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Kononova, T.E., Urazova, O.I., Novitskii, V.V. et al. Factors of Th17 and Treg Lymphocyte Differentiation in Pulmonary Tuberculosis. Bull Exp Biol Med 159, 201–204 (2015). https://doi.org/10.1007/s10517-015-2922-9

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  • DOI: https://doi.org/10.1007/s10517-015-2922-9

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