Considerable changes in serum lipids and lipoprotein profiles associated with hypertriglyceridemia, hypercholesterolemia, increased VLDL and LDL concentrations, and reduced HDL level occur at the early stages of streptozotocin-induced diabetes (day 7) in rats. The level of saturated palmitic fatty acid increased and the levels of monounsaturated fatty acids decreased at the expense of oleic acid, which considerably differed from changes in these parameters observed in patients with diabetes mellitus. Our fi ndings suggest that changes in the lipid composition and fatty acid pool in erythrocytes and liver homogenates are pro-atherosclerotic already in the early stages of diabetes development.
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References
A. A. Aleksandrov, Consilium Medicum, 5, No. 9, 509-513 (2003).
N. P. Mikaelyan, A. E. Gurina, Kh. Z. Nguen, et al., Ross. Med. Zh., No. 4, 33-38 (2014).
O. V. Serebryakova, A. V. Govorin, V. I. Prosyanik, and E. V. Baksheeva, Klin. Med., 86, No. 2, 40-43 (2008).
D. Chien, D. Dean, A. K. Saha, et al., Am. J. Physiol. Endocrinol. Metab., 279, No. 2, E259-E265 (2000).
J. Folch, M. Lees, and G. H. Sloane Stanley, J. Biol. Chem., 226, No. 1, 497-509 (1957).
A. Grynberg, Medicography, 21, No. 2, 29-35 (1999).
S. Halimi, A. Schweizer, B. Minic, et al., Vasc. Health Risk Manag., 4, No. 3, 481-492 (2008).
L. B. Harrison, B. Adams-Huet, Ph. Raskin, and I. Lingvay, Diabet. Care, 35, No. 7, 1406-1412 (2012).
S. Islam and D. T. Loots, Methods Find. Exp. Clin. Pharmacol., 31, No. 4, 249-261 (2009).
G. D. Lopaschuk, J. R. Ussher, C. D. Folmes, et al., Physiol. Rev., 90, No. 1, 207-258 (2010).
Y. Yagi, M. Matsuda, and K. Yagi, Experimentia, 32, No. 7, 905-906 (1976).
P. Zimmet, J. Shaw, and K. G. Alberti, Diabet. Med., 20, No. 9, 693-702 (2003).
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 159, No. 2, pp. 154-157, February, 2015
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Mikaelyan, N.P., Nguen, H.Z. & Terent’ev, A.A. Metabolic Abnormalities in Erythrocyte Membranes and Liver Tissue Homogenates in Experimental Diabetes Mellitus. Bull Exp Biol Med 159, 197–200 (2015). https://doi.org/10.1007/s10517-015-2921-x
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DOI: https://doi.org/10.1007/s10517-015-2921-x