We analyzed the effect of dipeptide Glu-Trp and isovaleroyl-Glu-Trp in concentrations of 0.2, 2 and 20 μg/ml and Actovegin preparation on functional activity of human skin fibroblasts. Dipeptides, especially Glu-Trp, produce a stimulating effect on human skin fibroblasts and their effect is equivalent to that of Actovegin. Dipeptides stimulate cell renewal processes by activating synthesis of Ki-67 and reducing expression of caspase-9 and enhance antioxidant function of the cells by stimulating the expression of Hsp-90 and inducible NO-synthase. These findings suggest that dipeptides are promising candidates for preparations stimulating reparative processes.
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Translated from Kletochnye Tekhnologii v Biologii i Meditsine, No. 1, pp. 52-55, January, 2015
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Malinin, V.V., Durnova, A.O., Polyakova, V.O. et al. Dipeptides Increase Functional Activity of Human Skin Fibroblasts. Bull Exp Biol Med 159, 164–167 (2015). https://doi.org/10.1007/s10517-015-2914-9
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DOI: https://doi.org/10.1007/s10517-015-2914-9