Skip to main content

Age-Specific and Individual Features of Vasopressinergic Regulation of the Hypothalamic–Pituitary–Adrenal System in Primates

Experimental study was carried out on young mature (6-8 years) and old (21-27 years) rhesus macaques with anxious and depression-like behavior and with standard (control) adaptive behavior. The responce of the adenohypophysis to arginine vasopressin depended on age and the type of adaptive behavior. Young animals with standard behavior demonstrated much higher concentrations of ACTH in the peripheral plasma in response to arginine vasopressin than old animals. The secretion of ACTH was higher in young and old animals with anxious and depressive-like adaptive behavior and they exhibited no age-specifi c differences in reaction to arginine vasopressin, which were observed in control animals. Preinjection of vasopressin V1b receptor antagonist to a female with high anxiety sharply reduced ACTH secretion in response to insulin-induced hypoglycemia in comparison with ACTH secretion under the same conditions without antagonist injection. These results suggested that the vasopressinergic system of animals with anxious and depressive behavior plays an important role in the regulation of ACTH secretion and in activity of the hypothalamic–pituitary–adrenal system in general.

This is a preview of subscription content, access via your institution.


  1. N. D. Goncharova and V. Yu. Marenin, Uspekhi Gerontol., 22, No. 4, 614-621 (2009).

    CAS  Google Scholar 

  2. N. D. Goncharova, V. Kh. Khavinson, and B. A. Lapin, The Pineal Gland and Age-Specifi c Diseases (Mechanisms and Correction) [in Russian], St. Petersburg (2007).

  3. G. Aguilera, Exp. Gerontol., 46, Nos. 2-3, 90-95 (2011).

  4. T. L. Bale and W. W. Vale, Annu. Rev. Pharmacol. Toxicol., 44, 525-557 (2004).

    Article  CAS  PubMed  Google Scholar 

  5. N. D. Goncharova, Primatology: Theories, Methods, and Research, Ed. E. Potocki, et al., New York (2009), pp. 29-52.

  6. N. D. Goncharova, V. Y. Marenin, and T. E. Oganyan, Aging (Albany NY), 2, No. 11, 854-866 (2010).

  7. N. D. Goncharova, Front. Endocrinol. (Lausanne), 4, 26 (2013).

    Google Scholar 

  8. N. D. Goncharova, V. Yu. Marenin, and A. A. Vengerin, Curr. Aging Sc., 6, No. 2, 163-169 (2013).

    Article  CAS  Google Scholar 

  9. B. S. McEwen, Physiol. Rev., 87, No. 3, 873-904 (2007).

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to N. D. Goncharova.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 158, No. 12, pp. 773-776, December, 2014

Rights and permissions

Reprints and Permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Goncharova, N.D., Oganyan, T.E., Marenin, V.Y. et al. Age-Specific and Individual Features of Vasopressinergic Regulation of the Hypothalamic–Pituitary–Adrenal System in Primates. Bull Exp Biol Med 158, 804–806 (2015).

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI:

Key Words