Nootropic Effect of Meadowsweet (Filipendula vulgaris) Extracts

The effects of the extracts of the aboveground parts of Filipendula vulgaris Moench on the behavior and memory of mice after hypoxic injury and their physical performance in the open-field test were studied using the models of hypoxia in a sealed volume, conditioned passive avoidance response (CPAR), and forced swimming with a load. The extracts improved animal resistance to hypoxia, normalized orientation and exploration activities, promoted CPAR retention after hypoxic injury, and increased physical performance. Aqueous extract of meadowsweet had the most pronounced effect that corresponded to the effect of the reference drug piracetam. These effects were probably caused by modulation of hippocampal activity.

This is a preview of subscription content, access via your institution.


  1. 1.

    V. N. Bubenchikova and Yu. A. Sukhomlinov, Farmatsiya, No. 3, 9-11 (2005).

  2. 2.

    Ya. Bures, O. Bureshova, and J.P. Houston, Techniques and Basic Experiments for Studying Brain and Behavior [in Russian], Moscow (1991).

  3. 3.

    A. V. Kaigorodtsev, Byull. Sib. Med., 9, No. 6, 93-98 (2010).

    Google Scholar 

  4. 4.

    G. V. Krylov, N. F. Kozakova, and E. V. Stepanov, Green Pharmacy [in Russian], Kemerovo (1993).

  5. 5.

    A. V. Batukhtin, I. V. Shilova, and N. I. Suslov, Patent RF No. 2394588, Agent Having Anxiolytic Effect, Byull. No. 20 from July 20, 2010.

  6. 6.

    Manual of Preclinical Studies of New Drugs, Ed. A. N. Mi ronov [in Russian], Part I, Moscow (2013)

  7. 7.

    Yu. A. Sukhomlinov, M. V. Pokrovskii, A. I. Konoplya, and O. N. Baginskiy, Vestn. Voronezhsk. Gos. Un-ta, Ser. Khim. Biol. Farmatsiya, No. 2, 209-213 (2005).

  8. 8.

    I. V. Shilova, N. I. Suslov, N. V. Provalova, et al., Vopr. Biol., Med. Farm. Khimii, No. 4, 24-26 (2008).

  9. 9.

    I. V. Shilova, N. I. Suslov, and I. A. Samylina, Chemical Composition and Nootropic Activity of Plants in Siberia [in Russian], Tomsk (2010).

  10. 10.

    D. S. Charney, Am. J. Psychiatry, 161, No. 2, 195-216 (2004).

    Article  PubMed  Google Scholar 

  11. 11.

    M. L. Popescu, V. Istudor, C. Parvu, et al., Farmacia (Romania), 50, No. 2, 34-38 (2002).

    CAS  Google Scholar 

  12. 12.

    M. L. Popescu, V. Istudor, C. Parvu, et al., Farmacia (Romania), 51, No. 4, 92-98 (2003).

    CAS  Google Scholar 

  13. 13.

    H. D. Smolarz, T. H. Dzido, and A. A. Sokolowska-Wozniak, Act. Polon. Pharmaceut. Drug Res., 56, No. 2, 169-172 (1999).

    CAS  Google Scholar 

  14. 14.

    H. D. Smolarz and A. A. Sokolowska-Wozniak, Chem. Environ. Res., 12, No. 1, 77-82 (2003).

    CAS  Google Scholar 

Download references

Author information



Corresponding author

Correspondence to I. V. Shilova.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 158, No. 11, pp. 609-613, November, 2014

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Shilova, I.V., Suslov, N.I. Nootropic Effect of Meadowsweet (Filipendula vulgaris) Extracts. Bull Exp Biol Med 158, 659–663 (2015).

Download citation

Key Words

  • Filipendula vulgaris Moench
  • conditioned passive avoidance response
  • open-field test
  • hypoxia, forced swimming