Skip to main content

Transformation of Catalytic Characteristics of Cerebral Monoamine Oxidases in Experimental Posttraumatic Stress Disorders

We studied the contribution of the transformation of the catalytic properties of cerebral monoamine oxidase in the development of behavioral disorders during stress. Monoamine oxidase activities and catalytic characteristics, LPO intensity, and oxidative modification of proteins in suspension of the brain mitochondria were evaluated over the course of experimental posttraumatic stress disorder. The detected shifts were comparable with the results of neuroethologic testing. The development of behavioral disorders presented by low exploratory activity and high anxiety was associated with transformation of catalytic characteristics of cerebral monoamine oxidases, associated with the development of oxidative stress with predominant intensification of metal-catalyzed protein oxidation.

This is a preview of subscription content, access via your institution.

References

  1. A. S. Avedisova, Zh. Nevrol. Psikhiatr. im. S. S. Korsakova, 109, No. 12, 46–49 (2009).

    CAS  PubMed  Google Scholar 

  2. I. A. Volchegorskii, I. I. Dolgushin, O. L. Kolesnikova, and V. E. Tseilikman, Experimental Simulation and Laboratory Evaluation of Adaptation Reactions [in Russian], Chelyabinsk (2000).

  3. V. Z. Gorkin, Aminoxidases and Their Significance in Medicine [in Russian], Moscow (1981).

  4. O. Yu. Maiorov, Klin. Informat. Telemed., 7, No. 8, 21–32 (2011).

    Google Scholar 

  5. T. A. Moskvitina and N. I. Solov’yova, Klin. Lab. Diagnost., No. 1, 3–7 (2011).

  6. A. L. Pushkarev, V. A. Domoratskii, and E. G. Gordeeva, Post traumatic Stress Disorders: Diagnosis, Psychopharmacotherapy, and Psychotherapy [in Russian], Moscow (2000).

  7. The Diagnostic and Statistical Manual of Mental Disorders, Arlington (2013), pp. 271–280.

  8. C. Belzung and G. Griebel, Behav. Brain. Res., 125, Nos. 1–2, 141–149 (2001).

    Article  CAS  PubMed  Google Scholar 

  9. H. Cohen, J. Zohar, M. A. Matar, et al., Neuropsychopharmacology, 29, No. 11, 1962–1970 (2004).

    Article  PubMed  Google Scholar 

  10. N. Pivac, J. Knezevic, D. Kozaric-Kovacic, et al., J. Affect. Disord., 103, Nos. 1–3, 131–138 (2007).

    Article  CAS  PubMed  Google Scholar 

  11. J. C. Shih, J. B. Wu, and K. Chen, J. Neural Transm., 118, No. 7, 979–986 (2011).

    Article  PubMed Central  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to A. I. Sinitskii.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 158, No. 11, pp. 591–593, November, 2014

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Kolesnikova, L.I., Popova, A.S., Deev, R.V. et al. Transformation of Catalytic Characteristics of Cerebral Monoamine Oxidases in Experimental Posttraumatic Stress Disorders. Bull Exp Biol Med 158, 641–643 (2015). https://doi.org/10.1007/s10517-015-2826-8

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10517-015-2826-8

Key Words

  • monoamine oxidase
  • posttraumatic stress disorder
  • free radical oxidation