Serum Levels of Neurosteroids in Patients with Affective Disorders
According modern biological hypotheses of the pathogenesis of affective disorders, hypothalamic–pituitary–adrenal axis dysfunction play a special role in the pathogenesis of this condition. Our study shows that the range of neuroprotective neurosteroids is gender- and nosology-dependent. Patients with affective disorders have reduced levels of dehydroepiandrosterone and dehydroepiandrosterone sulfate; the most pronounced defi ciency of neuroprotective neurosteroids is typical of patients with a single depressive episode. Reduced levels of neurosteroids producing an anabolic effect probably indicate depletion of adaptive capacities of the hypothalamic–pituitary–adrenal system in affective disorders.
Key Wordsaffective disorders dehydroepiandrosterone dehydroepiandrosterone sulfate
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- 1.N. A. Bokhan, S. A. Ivanova, and L. A. Levchuk, Serotonin System in the Modulation of Depressive and Aggressive Behavior [in Russian], Tomsk (2013).Google Scholar
- 2.N. P. Goncharov, G. V. Katsiya, and A. N. Nizhnik, Vestn. Ross. Akad. Med. Nauk, No. 8, 37–43 (2005).Google Scholar
- 3.S. A. Ivanova, L. A. Levchuk, E. V. Gutkevich, and V. Ya. Semke, Psikhiatriya, No. 3, 18–22 (2010).Google Scholar
- 4.Ya. A. Kochetkov, K. V. Bel’tikova, and L. N. Gorobets, Zh. Psikhiatr. Nevrol. im. S. S. Korsakova, 106, No. 10, 47–51 (2006).Google Scholar
- 5.V. N. Krasnov, Psikh. Rasstroystva Obshchey Meditsine, No. 2, 12–15 (2012).Google Scholar
- 6.E. V. Lebedeva, E. V. Gutkevich, S. A. Ivanova, et al., Sib. Vestn. Psikhiatr. Narkol., No. 6, 41–46 (2012).Google Scholar
- 7.V. A. Stoyak, E. V. Zhernova, N. A. Bokhan, and S. A. Ivanova, Sib. Vestn. Psikhiatr. Narkol., No. 4, 88–90 (2010).Google Scholar