Bulletin of Experimental Biology and Medicine

, Volume 158, Issue 5, pp 638–640 | Cite as

Serum Levels of Neurosteroids in Patients with Affective Disorders

  • L. A. LevchukEmail author
  • N. M. Vyalova
  • S. A. Ivanova
  • G. G. Simutkin
  • E. V. Lebedeva
  • N. A. Bokhan

According modern biological hypotheses of the pathogenesis of affective disorders, hypothalamic–pituitary–adrenal axis dysfunction play a special role in the pathogenesis of this condition. Our study shows that the range of neuroprotective neurosteroids is gender- and nosology-dependent. Patients with affective disorders have reduced levels of dehydroepiandrosterone and dehydroepiandrosterone sulfate; the most pronounced defi ciency of neuroprotective neurosteroids is typical of patients with a single depressive episode. Reduced levels of neurosteroids producing an anabolic effect probably indicate depletion of adaptive capacities of the hypothalamic–pituitary–adrenal system in affective disorders.

Key Words

affective disorders dehydroepiandrosterone dehydroepiandrosterone sulfate 


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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • L. A. Levchuk
    • 1
    Email author
  • N. M. Vyalova
    • 1
  • S. A. Ivanova
    • 1
  • G. G. Simutkin
    • 1
  • E. V. Lebedeva
    • 1
  • N. A. Bokhan
    • 1
    • 2
  1. 1.Mental Health Research InstituteSiberian Division of Russian Academy of Medical SciencesTomskRussia
  2. 2.National Research Tomsk State UniversityTomskRussia

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