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The Use of Automated System for EEG Analysis and Feedback Cerebral Stimulation to Stop Epileptiform Activity in WAG/Rij Rats

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Original software program is described, which revealed EEG activity characteristic of the onset of epileptic seizure and turned on electrical stimulation of the nucleus basalis of Meynert in WAG/Rij rats with congenital absence epilepsy. The program reliably detected the onset of seizure and automatically stopped it with a high-frequency train of electrical impulses (100-150 Hz). Thus, a feedback system of deep brain stimulation has been developed to stop early manifestations of absence epileptiform seizures. The study can be a base to develop an implanted apparatus to automatically analyze EEG and stimulate the brain to stop the epileptic seizures.

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Authors and Affiliations

  1. Biological Faculty, M. V. Lomonosov Moscow State University, Moscow, Russia

    V. A. Blik, A. V. Aristov & N. E. Chepurnova

Authors
  1. V. A. Blik
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  2. A. V. Aristov
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  3. N. E. Chepurnova
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Correspondence to V. A. Blik.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 158, No. 10, pp. 525-528, October 2014

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Blik, V.A., Aristov, A.V. & Chepurnova, N.E. The Use of Automated System for EEG Analysis and Feedback Cerebral Stimulation to Stop Epileptiform Activity in WAG/Rij Rats. Bull Exp Biol Med 158, 520–522 (2015). https://doi.org/10.1007/s10517-015-2799-7

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  • DOI: https://doi.org/10.1007/s10517-015-2799-7

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