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P388 Leukemia in CDF1 Mice as the Test System for Studies of Tumor-Associated Neoangiogenesis and Hypercoagulation

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Blood levels of vascular endothelial growth factor, the main marker of angiogenesis activity, and coagulation hemostasis were studied in CDF1 mice with transplanted P-388 lymphocytic leukemia. Blood levels of vascular endothelial growth factor increased by 168% in mice with tumors. The animals developed the hypercoagulation syndrome manifesting in shorter activated partial thromboplastin time and prothrombin time and development of hyperfibrinogenemia.

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Authors and Affiliations

  1. St. Petersburg State Pediatric Medical University, the Ministry of Health of the Russian Federation, St. Petersburg, Russia

    A. P. Trashkov, A. V. Panchenko, E. S. Kayukova, R. V. Korablev, V. A. Pechatnikova & A. G. Vasil’ev

  2. N. N. Petrov Research Institute of Oncology, Ministry of Health of the Russian Federation, St. Petersburg, Russia

    A. V. Panchenko & V. N. Anisimov

Authors
  1. A. P. Trashkov
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  2. A. V. Panchenko
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  3. E. S. Kayukova
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  4. R. V. Korablev
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  5. V. A. Pechatnikova
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  6. A. G. Vasil’ev
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  7. V. N. Anisimov
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Corresponding author

Correspondence to A. P. Trashkov.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 158, No. 10, pp. 500-502, October, 2014

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Trashkov, A.P., Panchenko, A.V., Kayukova, E.S. et al. P388 Leukemia in CDF1 Mice as the Test System for Studies of Tumor-Associated Neoangiogenesis and Hypercoagulation. Bull Exp Biol Med 158, 497–499 (2015). https://doi.org/10.1007/s10517-015-2793-0

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  • DOI: https://doi.org/10.1007/s10517-015-2793-0

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