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Effect of Selective Blockade of α2-Adrenoceptor Subtypes on Cardiovascular System in Rats

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Selective blockade of various α2-adrenoceptors exerts various effects on the cardiovascular system in rats. Blockade of α2A/D-adrenoceptors in experimental animals decelerates and then accelerates HR. Blockade of α2B-adrenoceptors produces a negative chronotropic effect; blockade of α2C-adrenoceptors has a positive chronotropic effect. Administration of selective blockers of α2A/D- and α2B-adrenoceptors causes hypotension, while selective blockade of α2C-adrenoceptors increases BP.

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Authors and Affiliations

  1. Department of Anatomy, Physiology and Human Health Protection, Kazan (Volga Region) Federal University, Kazan, Russia

    T. L. Zefirov, L. I. Khisamieva & N. I. Ziyatdinova

  2. Department of Normal Physiology, Kazan State Medical University, Kazan, Russia

    A. L. Zefirov

Authors
  1. T. L. Zefirov
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  2. L. I. Khisamieva
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  3. N. I. Ziyatdinova
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  4. A. L. Zefirov
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Correspondence to T. L. Zefirov.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 158, No. 10, pp. 406-408, October, 2014

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Zefirov, T.L., Khisamieva, L.I., Ziyatdinova, N.I. et al. Effect of Selective Blockade of α2-Adrenoceptor Subtypes on Cardiovascular System in Rats. Bull Exp Biol Med 158, 410–412 (2015). https://doi.org/10.1007/s10517-015-2774-3

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  • DOI: https://doi.org/10.1007/s10517-015-2774-3

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