A simple method for the diagnosis of insulin resistance, easily realized in clinical practice, is developed in order to detect patients at a high risk of diseases associated with this condition. The metabolic index is estimated as the proportion of triglycerides and glucose values to quadratic HDL cholesterol value (in mmol/liter). The specifi c feature of this method for detection of insulin resistance in comparison with the known indirect methods is the use of routine biochemical values, evaluated in venous serum, for estimations. Estimation of this metabolic index is an economic and effective indirect method for evaluating the homeostasis system without additional evaluation of blood hormones.
Similar content being viewed by others
References
E. K. Alisheva, E. I. Krasilnikova, and E. V. Shlyakhto, Arterial. Gipertenz., 8, No. 1, 29-34 (2002).
The Metabolic Syndrome [in Russian], Ed. G. E. Roitberg, Moscow (2007).
G. E. Roitberg, T. I. Ushakova, Zh. V. Dorosh, et al., Patent RF No. 2493566. A Method for Screening Diagnosis of Insulin Resistance, Bull. No. 26, September 20, 2013.
N. V. Perova, V. A. Metelskaya, and R. G. Oganov, Kardiologiya, No. 3, 4-9 (2001).
G. E. Roitberg, T. I. Ushakova, and Zh. V. Dorosh, Kardiologiya, 44, No. 3, 94-101 (2004).
G. E. Roitberg, T. I. Ushakova, O. O. Sharkhun, and Zh. V. Dorosh, Kardiologiya, 52, No. 10, 45-50 (2012).
K. G. Alberti and P. Z. Zimmet, Diabet. Med., 15, No. 7, 539-553 (1998).
R. N. Bergman, D. T. Finegood, and M. Ader, Endocr. Rev., 6, No. 1, 45-86 (1985).
E. Borona, P. Moghetti, C. Zancanaro, et al., J. Clin. Endocrinol. Metab., 68, No. 2, 374-378 (1989).
A. Mari, Am. J. Physiol., 272, No. 5, Pt. 1, E925-E934 (1997).
D. R. Matthews, J. P. Hosker, A. S. Rudenski, et al., Diabetologia, 28, No. 7, 412-419 (1985).
T. McLaughlin, G. Reaven, F. Abbasi, et al., Am. J. Cardiol., 96, No. 3, 399-404 (2005).
G. M. Reaven, Diabetes, 37, No. 12, 1595-1607 (1988).
A. J. Scheen, N. Paquot, M. J. Castillo, and P. J. Lefébvre, Diabetes Metab. Rev., 10, No. 2, 151-188 (1994).
D. Tripathy, M. Carlsson, P. Almgren, et al., Diabetes, 49, No. 6, 975-980 (2000).
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 158, No. 9, pp. 389-392, September, 2014
Rights and permissions
About this article
Cite this article
Roitberg, G.E., Dorosh, Z.V. & Sharkhun, O.O. A New Method for Screening Diagnosis of Insulin Resistance. Bull Exp Biol Med 158, 397–400 (2015). https://doi.org/10.1007/s10517-015-2771-6
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10517-015-2771-6