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Cerebroprotective and Regenerative Effects of Alkaloid Z77 under Conditions of Brain Ischemia

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Bulletin of Experimental Biology and Medicine Aims and scope

We studied the psychopharmacological effects of atisine-type diterpene alkaloid Z77 in a rat model of cerebral ischemia. Pronounced cerebroprotective effect was found consisting in normalization of the orienting and exploratory activity and conditioned behavior associated with significant correction of morphological changes in the brain. The direct stimulatory effect of Z77 on neural stem cells was shown in vitro.

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References

  1. E. D. Goldberg, A. M. Dygai, and G. N. Zyuz’kov, Hypoxia and Blood System [in Russian], Tomsk (2006).

  2. A. M. Dygai, G. N. Zyuz’kov, V. V. Zhdanov, et al., Manual of Preclinical Studies of New Drugs, [in Russian], Part I, Ed. A. N. Mironov, Moscow (2013), pp. 776-787.

  3. G. N. Zyuz’kov, M. G. Danilets, A. A. Ligacheva, et al., Bull. Exp. Biol. Med., 157, No. 3, 353-356 (2014).

    Article  PubMed  Google Scholar 

  4. G. N. Zyuz’kov, A. V. Chaikovskii, A. A. Ligacheva, et al., Bull. Exp. Biol. Med., 157, No. 1, 146-149 (2014).

    Article  PubMed  Google Scholar 

  5. P. Curzon, Zhang Min, R. J. Radek, and G. B. Fox, Methods of Behavior Analysis in Neuroscience, Ed. J. J. Buccafusco, Boca Raton; London; New York (2009), pp. 145-178.

  6. A. M. Dygai, G. N. Zyuz’kov, V. V. Zhdanov, et al., Stem Cell Rev., 9, No. 2, 140-147 (2013).

    Article  CAS  PubMed  Google Scholar 

  7. E. D. Goldberg, A. M. Dygai, G. N. Zyuz’kov, and V. V. Zhdanov, Bull. Exp. Biol. Med., 144, No. 6, 802-805 (2007).

    Article  CAS  PubMed  Google Scholar 

  8. E. D. Goldberg, A. M. Dygai G. N. Zyuz’kov, et al., Bull. Exp. Biol. Med., 143, No. 4, 548-551 (2007).

    Article  CAS  PubMed  Google Scholar 

  9. M. B. Plotnikov, S. V. Logvinov, N. I. Suslov, et al., New Trends in Brain Hypoxia Ishemia Research, Ed. Etu Hеmеlеinien, New York (2008), pp. 93-133.

  10. G. N. Zyuz’kov, A. V. Krapivin, Yu. V. Nesterova, et al., Bull. Exp. Biol. Med., 153, No. 6, 846-850 (2012).

    PubMed  Google Scholar 

  11. G. N. Zyuz’kov, V. V. Zhdanov, L. A. Miroshnichenko, et al., Bull. Exp. Biol. Med., 155, No. 3, 350-353 (2013).

    Article  PubMed  Google Scholar 

  12. G. N. Zyuz’kov, V. V. Zhdanov, E. V. Udut, et al., Bull. Exp. Biol. Med., 155, No. 4, 439-442 (2013).

    Article  PubMed  Google Scholar 

  13. G. N. Zyuz’kov, L. A. Gur’yantseva, E. V. Simanina, et al., Bull. Exp. Biol. Med., 143, No. 4, 535-538 (2007).

    Article  PubMed  Google Scholar 

  14. G. N. Zyuz’kov, V. V. Zhdanov, A. M. Dygai, et al., Bull. Exp. Biol. Med., 144, No. 6, 840-845 (2007).

    Article  PubMed  Google Scholar 

  15. G. N. Zyuz’kov, N. I. Suslov, A. M. Dygai, et al., Bull. Exp. Biol. Med., 140, No. 5, 606-611 (2005).

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. E. D. Goldberg Research Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia

    G. N. Zyuz’kov, N. I. Suslov, E. A. Losev, L. A. Ermolaeva, V. V. Zhdanov, E. V. Udut, L. A. Miroshnichenko, E. V. Simanina, T. N. Povet’eva, Yu. V. Nesterova, V. V. Udut, M. Yu. Minakova & A. M. Dygai

  2. National Research Tomsk State University, Tomsk, Russia

    G. N. Zyuz’kov, N. I. Suslov, V. P. Demkin & V. V. Udut

Authors
  1. G. N. Zyuz’kov
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  2. N. I. Suslov
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  3. E. A. Losev
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  4. L. A. Ermolaeva
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  5. V. V. Zhdanov
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  6. E. V. Udut
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  7. L. A. Miroshnichenko
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  8. E. V. Simanina
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  9. V. P. Demkin
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  10. T. N. Povet’eva
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  11. Yu. V. Nesterova
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  12. V. V. Udut
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  13. M. Yu. Minakova
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  14. A. M. Dygai
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Corresponding author

Correspondence to G. N. Zyuz’kov.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 158, No. 9, pp. 339-343, September, 2014

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Zyuz’kov, G.N., Suslov, N.I., Losev, E.A. et al. Cerebroprotective and Regenerative Effects of Alkaloid Z77 under Conditions of Brain Ischemia. Bull Exp Biol Med 158, 352–355 (2015). https://doi.org/10.1007/s10517-015-2760-9

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  • DOI: https://doi.org/10.1007/s10517-015-2760-9

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