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Hepatoprotective Properties of Betulonic Acid Amide and Heptral in Toxic Liver Injury Induced by Carbon Tetrachloride in Combination with Ethanol

Bulletin of Experimental Biology and Medicine volume 158, pages 336–341 (2015)Cite this article

Toxic liver injury with the development of fi brosis and cirrhosis was modeled in Wistar rats by intragastric administration of 0.1 ml/kg CCl4 in combination with 5% ethanol with glucose 3 times a week for 6 weeks. The animals were treated with betulonic acid amide (50 mg/kg in Tween aqueous solution) and heptral (6 mg/kg) as hepatoprotective compounds. It was found that betulonic acid amide stimulated the regenerative response in hepatocytes under conditions of combined toxic exposure and promoted recovery of their qualitative and quantitative characteristics, which was accompanied by a signifi cant decrease in the severity of liver fi brosis and the absence of cirrhotic transformation of the liver.

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References

  1. Kh. E. Blum, Ross. Zh. Gastroenterol. Gepatol. Koloproktol., 17, No. 5, 11-15 (2007).

    Google Scholar 

  2. D. V. Garbuzenko, Ross. Zh. Gastroenterol. Gepatol. Koloproktol., 18, No. 6, 14-21 (2008).

    Google Scholar 

  3. N. A. Zhukova, D. E. Semenov, E. P. Bessergeneva, et al., Bull. Exp. Biol. Med., 154, No. 3, 370-374 (2013).

    CAS  PubMed  Article  Google Scholar 

  4. O. P. Molodykh, E. L. Lushnikova, M. G. Klinnikova, and L. M. Nepomnyashchikh, Bull. Exp. Biol. Med., 144, No. 4, 580-587 (2007).

    CAS  PubMed  Article  Google Scholar 

  5. D. L. Nepomnyashchikh, S. V. Aydagulova, and G. I. Nepomnyashchikh, Liver Biopsy: Pathomorphogenesis of Chronic Hepatitis and Cirrhosis [in Russian], Moscow (2006).

  6. S. V. Okovityi, N. N. Bezborodkina, S. G. Uleichik, and S. N. Shulenin, Hepatoprotectors [in Russian], Moscow (2010).

  7. D. E. Semenov, N. A. Zhukova, E. P. Bessergeneva, et al., Bull. Exp. Biol. Med., 153, No. 6, 859-862 (2012).

    CAS  Article  Google Scholar 

  8. I. V. Sorokina, T. G. Tolstikova, N. A. Zhukova, et al., Bull. Exp. Biol. Med., 142, No. 1, 51-54 (2006).

    CAS  PubMed  Article  Google Scholar 

  9. T. G. Tolstikova, I. V. Sorokina, and G. A. Tolstikov, Bioorgan. Khimiya, 32, No. 3, 291-307 (2006).

    CAS  Google Scholar 

  10. T. G. Tolstikova, N. A. Zhukova, D. E. Semenov, et al., Fundament. Issled., No. 5, 120-123 (2012).

    Google Scholar 

  11. M. Karin and F. R. Greten, Nat. Rev. Immunol., 5, No. 10, 749-759 (2005).

    CAS  PubMed  Article  Google Scholar 

  12. K. T. Liby, M. M. Yore, and M. V. Sporn, Nat. Rev. Cancer., 7, No. 5, 357-369 (2007).

    CAS  PubMed  Article  Google Scholar 

  13. J. L. Luo, H. Kamata, and M. Karin, J. Clin. Invest., 115, No. 10, 2625-2632 (2005).

    CAS  PubMed Central  PubMed  Article  Google Scholar 

  14. N. C. Teoh and G. C. Farrell, J. Gastroenterol. Hepatol., 18, No. 8, 891-902 (2003).

    CAS  PubMed  Article  Google Scholar 

  15. H. Tsukamoto, M. Matsuoka, and S. W. French, Semin. Liver Dis., 10, No. 1, 56-65 (1990).

    CAS  PubMed  Article  Google Scholar 

Download references

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Affiliations

  1. N. N. Vorozhtsov Novosibirsk Institute for Organic Chemistry, Siberian Division of Russian Academy of Sciences, Novosibirsk, Russia

    N. A. Zhukova, E. P. Ivanova, I. V. Sorokina, D. S. Baiev, T. G. Tolstikova & M. S. Biryukova

  2. Research Institute for Regional Pathology and Pathomorphology, Siberian Division of Russian Academy of Medical Sciences, Novosibirsk, Russia

    D. E. Semenov & G. I. Nepomnyashchikh

Authors
  1. D. E. Semenov
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  2. N. A. Zhukova
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  3. E. P. Ivanova
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  4. I. V. Sorokina
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  5. D. S. Baiev
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  6. G. I. Nepomnyashchikh
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  7. T. G. Tolstikova
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  8. M. S. Biryukova
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Corresponding author

Correspondence to D. E. Semenov.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 158, No. 9, pp. 320-326, September, 2014

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Semenov, D.E., Zhukova, N.A., Ivanova, E.P. et al. Hepatoprotective Properties of Betulonic Acid Amide and Heptral in Toxic Liver Injury Induced by Carbon Tetrachloride in Combination with Ethanol. Bull Exp Biol Med 158, 336–341 (2015). https://doi.org/10.1007/s10517-015-2756-5

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  • DOI: https://doi.org/10.1007/s10517-015-2756-5

Key Words

  • toxic liver injury
  • cirrhosis
  • cytoprotection
  • carbon tetrachloride
  • betulonic acid amide