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Effect of Phosphocreatine and Ethylmethylhydroxypyridine Succinate on the Expression of Bax and Bcl-2 Proteins in Left-Ventricular Cardiomyocytes of Spontaneously Hypertensive Rats

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We studied the effect of phosphocreatine and ethylmethylhydroxypyridine succinate on the expression of Bax and Bcl-2 proteins in left-ventricular cardiomyocytes of spontaneously hypertensive rats (SHR). Both drugs have no effect on the expression of Bcl-2, but significantly reduce the level of Bax protein (phosphocreatine produces more pronounced effect). These data attest to an important role of energy deficit and oxidative stress in the induction of cardiomyocyte apoptosis in genetically determined arterial hypertension.

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Authors and Affiliations

  1. Department of General Pathology and Pathophysiology, People’s Friendship University of Russia, Moscow, Russia

    M. M. Azova, M. L. Blagonravov & V. A. Frolov

Authors
  1. M. M. Azova
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  2. M. L. Blagonravov
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  3. V. A. Frolov
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Correspondence to M. M. Azova.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 158, No. 9, pp. 293–295, September, 2014

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Azova, M.M., Blagonravov, M.L. & Frolov, V.A. Effect of Phosphocreatine and Ethylmethylhydroxypyridine Succinate on the Expression of Bax and Bcl-2 Proteins in Left-Ventricular Cardiomyocytes of Spontaneously Hypertensive Rats. Bull Exp Biol Med 158, 313–314 (2015). https://doi.org/10.1007/s10517-015-2749-4

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  • DOI: https://doi.org/10.1007/s10517-015-2749-4

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