In 1.5 months after modeling of streptozotocin-induced diabetes mellitus, superoxide dismutase and catalase activities decreased by 40.7 and 32.0%, respectively, in comparison with the corresponding values in Wistar rats without diabetes. Electric stimulations (100 Hz, 0.25 msec, 50-100 μA, 2.5 sec) of the paleocerebellar cortex (V-VII lobules) were conducted 3 times a day over 1 month. These stimulations prevented the decrease in antioxidant enzyme activity in rats with experimental diabetes.
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References
A. R. Gnatush, V. R. Drel’, A. Ya. Yalanetskii, et al., Studia Biologica, 5, No. 2, 61-72 (2011).
L. S. Godlevskii, E. V. Kobolev, V. F. Mustyatsa, and G. A. Drozdova, Modeling and Mechanisms of Suppression of Experimental Epileptic Syndrome [in Russian], Odessa (2010).
M. A. Korolyuk, I. G. Ivanova, and I. G. Maiorova, Lab. Delo, No. 1, 16-18 (1988).
S. Chevari, T. D. Andyal, and D. Shtirenger, Lab. Delo, No. 10, 9-13 (1991).
S. M. Berman, G. Paz-Filho, M. L. Wong, et al., Cerebellum, 12, No. 1, 59-67 (2013).
A. D. Ding, H. Zhang, and J. M. Wang, Zhonghua Yan Ke Za Zhi, 40, No. 6, 400-403 (2004).
R. A. Kowluru, R. L. Engerman, G. L. Case, and T. S. Kern, Neurochem. Int., 38, No. 5, 385-390 (2001).
C. E. Oldreive, J. Harvey, G. H. Doherty, Neurosci. Lett., 438, No. 1, 17-21 (2008).
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 158, No. 8, pp. 168-170, August, 2014
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Kresyun, N.V., Godlevskii, L.S. Superoxide Dismutase and Catalase Activities in the Retina during Experimental Diabetes and Electric Stimulation of the Paleocerebellar Cortex. Bull Exp Biol Med 158, 206–208 (2014). https://doi.org/10.1007/s10517-014-2723-6
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DOI: https://doi.org/10.1007/s10517-014-2723-6