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Biochemical Markers of Bone Metabolism in Breast Cancer

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Bulletin of Experimental Biology and Medicine Aims and scope

The relationship between biochemical markers of bone resorption (C-terminal telopeptide, deoxypyridinoline, tartrate-resistant acid phosphatase 5b) and osteosynthesis (bone alkaline phosphatase) and clinical manifestations of bone metastases were studied in 239 patients with breast cancer with and without signs of bone involvement. High levels of C-terminal telopeptide and bone alkaline phosphatase were associated with poor prognosis: more severe skeletal complications and lesser survival values. These biochemical markers can be used for prognosis and optimization of therapy for bone metastases in patients with breast cancer.

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Authors and Affiliations

  1. N. N. Blokhin Russian Cancer Research Center, the Russian Academy of Medical Sciences, Moscow, Russia

    N. V. Lyubimova, G. V. Kozharskaya, S. M. Portnoi & N. E. Kushlinskii

Authors
  1. N. V. Lyubimova
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  2. G. V. Kozharskaya
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  3. S. M. Portnoi
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  4. N. E. Kushlinskii
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Corresponding author

Correspondence to N. V. Lyubimova.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 157, No. 6, pp. 740-744, June, 2014

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Lyubimova, N.V., Kozharskaya, G.V., Portnoi, S.M. et al. Biochemical Markers of Bone Metabolism in Breast Cancer. Bull Exp Biol Med 157, 769–772 (2014). https://doi.org/10.1007/s10517-014-2663-1

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  • DOI: https://doi.org/10.1007/s10517-014-2663-1

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