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Temporal Characteristics of Stress-Induced Decrease in Benzodiazepine Reception in C57Bl/6 and BALB/c Mice

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We studied the duration of the drop of specific 3H-flunitrazepam binding by synaptosomal membranes from the brain of C57Bl/6 and BALB/c mice after open-field and “contact with predator” tests. It was found that reduced benzodiazepine reception in BALB/c mice after open-field test persisted for 1.5 h, but no changes of this parameter were found in C57Bl/6 mice. After contact with predator, the binding capacity of the benzodiazepine site of GABAA receptor was reduced for 8 h in BALB/c mice and for 24 h in C57Bl/6 mice.

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References

  1. Manual of Preclinical Studies of New Drugs [in Russian], Ed. A. N. Mironov, Part I, Moscow (2012).

  2. S. B. Seredenin, M. A. Yarkova, and M. V. Voronin, Eksp. Klin. Farmakol., 64, No. 1, 63-65 (2001).

    PubMed  CAS  Google Scholar 

  3. K. S. Chekina, M. A. Yarkova, and S. B. Seredenin, Bull. Exp. Biol. Med., 148, No. 4, 606-608 (2010).

    Article  Google Scholar 

  4. R. Adamec, G. D. Bartoszyk, and P. Burton, Eur. J. Pharmacol., 504, Nos. 1-2, 65-77 (2004).

    Article  PubMed  CAS  Google Scholar 

  5. R. Adamec, D. Fougere, and V. Risbrough, Int. J. Neuropsychopharmacol., 13, No. 6, 747-757 (2010).

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  6. R. Adamec, M. Hebert, and J. Blundell, Behav. Brain Res., 221, No. 1, 117-133 (2011).

    Article  Google Scholar 

  7. R. Adamec, C. Muir, M. Grimes, and K. Pearcey, Behav. Brain Res., 179, No. 2, 192-207 (2007).

    Article  PubMed  CAS  Google Scholar 

  8. R. Adamec, M. Toth, J. Haller, and J. Blundell, Neuropharmacology, 62, No. 2, 725-736 (2012).

    Article  PubMed  CAS  Google Scholar 

  9. J. Blundell, R. Adamec, and P. Burton, Physiol. Behav., 86, Nos. 1-2, 233-243 (2005).

    Article  PubMed  CAS  Google Scholar 

  10. J. D. Bremner, Expert Rev. Neurother., 4, No. 2, 275-284 (2004).

    Article  PubMed  Google Scholar 

  11. S. I. Deutsch, R. B. Rosse, and J. Mastropaolo, Clin. Neuropharmacol., 17, No. 3, 205-228 (1994).

    Article  PubMed  CAS  Google Scholar 

  12. K. Holzschneider and C. Mulert, Dialogues Clin. Neurosci., 13, No. 4, 453-461 (2011).

    PubMed  PubMed Central  Google Scholar 

  13. H. Mohler, J. M. Fritschy, K. Vogt, et al., Handb. Exp. Pharmacol., 169, 225-247 (2005).

    Article  PubMed  Google Scholar 

  14. U. Rudolph and F. Knoflach, Nat. Rev. Drug. Discov., 10, No. 9, 685-697 (2011).

    Article  PubMed  CAS  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. Department of Pharmacogenetics, V. V. Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia

    M. A. Yarkova & S. B. Seredenin

Authors
  1. M. A. Yarkova
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  2. S. B. Seredenin
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Correspondence to M. A. Yarkova.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 157, No. 6, pp. 733-735, June, 2014

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Yarkova, M.A., Seredenin, S.B. Temporal Characteristics of Stress-Induced Decrease in Benzodiazepine Reception in C57Bl/6 and BALB/c Mice. Bull Exp Biol Med 157, 762–764 (2014). https://doi.org/10.1007/s10517-014-2661-3

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  • DOI: https://doi.org/10.1007/s10517-014-2661-3

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