The spectrum of antibodies to reproductive hormones and the diagnostic significance of their measurements in threatened abortion during trimester I were studied. Enhanced production of antibodies to hormones was detected by ELISA in patients with threatened abortion (N=44) in comparison with women with normal gestation (N=30). These antibodies were detected more often than antiphospholipid antibodies (p<0.05). Antibodies to chorionic gonadotropin (IgM, IgG) and gonadotropin-releasing hormone (IgG) were associated with threatened abortion. According to ROC analysis, their measurements were diagnostically significant in this pathology (AUC>0.8). Subclasses IgG1 and IgG2 predominated among IgG to chorionic gonadotropin. Presumably, antibodies to chorionic gonadotropin and gonadotropin-releasing hormone could serve as independent factors of threatened abortion risk during trimester I.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 157, No. 6, pp. 717-720, June, 2014
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Menzhinskaya, I.V., Van’ko, L.V., Kiryushchenkov, P.A. et al. Spectrum of Antibodies to Reproductive Hormones in Threatened Abortion. Bull Exp Biol Med 157, 747–750 (2014). https://doi.org/10.1007/s10517-014-2658-y
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DOI: https://doi.org/10.1007/s10517-014-2658-y