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Experimental Investigation of Pharmacodynamics and Pharmacokinetics of Carbamazepine Nanoemulsion

Anticonvulsant activity and pharmacokinetics of nanoemulsion and unmodified substance of carbamazepine were compared in experiments on mice. Carbamazepine nanoemulsion demonstrated significant anticonvulsant activity and was superior to unmodified substance of carbamazepine against seizures induced by maximum electric shock and picrotoxin. Relative bioavailability of carbamazepine after administration of nanoemulsion was 160% compared to unmodified substance. Carbamazepine nanoemulsion more effectively penetrated through BBB by 1.5 times in comparison with unmodified substance.

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Correspondence to D. I. Prokhorov.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 157, No. 6, pp. 712-716, June, 2014

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Prokhorov, D.I., Sariev, A.K., Abramov, D.A. et al. Experimental Investigation of Pharmacodynamics and Pharmacokinetics of Carbamazepine Nanoemulsion. Bull Exp Biol Med 157, 742–746 (2014). https://doi.org/10.1007/s10517-014-2657-z

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  • DOI: https://doi.org/10.1007/s10517-014-2657-z

Key Words

  • carbamazepine
  • nanoemulsion
  • pharmacokinetics
  • anticonvulsant activity
  • relative bioavailability