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Dual Effects of Indoleamine 2,3-Dioxygenase Inhibitors on the Therapeutic Effects of Cyclophosphamide and Cycloplatam on Ehrlich Ascites Tumor in Mice

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Bulletin of Experimental Biology and Medicine Aims and scope

Ethyl pyruvate, an inhibitor of indoleamine 2,3-dioxygenase, slightly suppressed the growth of transplantable Ehrlich tumor in mice and signifi cantly potentiated the therapeutic effect of cyclophosphamide. Another inhibitor amidoxime produced a similar effect. However, both ethyl pyruvate and amidoxime signifi cantly reduced the effect of cycloplatam therapy. The observed changes can be stipulated by different effects of cyclophosphamide and cycloplatam on the subpopulations of lymphoid cells taking part in the formation of antitumor immunity and resistance to tumors.

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Authors and Affiliations

  1. Research Institute of Regional Pathology and Pathomorphology, Siberian Division of Russian Academy of Medical Sciences, Novosibirsk, Russia

    L. A. Bogdanova & T. S. Morozkova

  2. N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Division of Russian Academy of Science, Novosibirsk, Russia

    S. A. Amitina, D. G. Mazhukin, N. A. Popova & V. I. Kaledin

  3. Institute of Cytology and Genetics, Siberian Division of Russian Academy of Science, Novosibirsk, Russia

    V. P. Nikolin

Authors
  1. L. A. Bogdanova
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  2. T. S. Morozkova
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  3. S. A. Amitina
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  4. D. G. Mazhukin
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  5. V. P. Nikolin
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  6. N. A. Popova
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  7. V. I. Kaledin
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Corresponding author

Correspondence to L. A. Bogdanova.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 157, No. 4, pp. 507-510, April, 2013

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Bogdanova, L.A., Morozkova, T.S., Amitina, S.A. et al. Dual Effects of Indoleamine 2,3-Dioxygenase Inhibitors on the Therapeutic Effects of Cyclophosphamide and Cycloplatam on Ehrlich Ascites Tumor in Mice. Bull Exp Biol Med 157, 506–509 (2014). https://doi.org/10.1007/s10517-014-2602-1

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  • DOI: https://doi.org/10.1007/s10517-014-2602-1

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