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Analgesic Activity of Diterpene Alkaloids from Aconitum Baikalensis

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We compared analgesic activities of individual alkaloids extracted from Baikal aconite (Aconitum baikalensis): napelline, hypaconitine, songorine, mesaconitine, 12-epinapelline N-oxide. The detected analgesic activity was comparable to that of sodium metamizole. The mechanisms of analgesia were different in diterpene alkaloids of different structure. The antinociceptive effect of atisine alkaloids (12-epinapelline N-oxide, songorine) was naloxonedependent and realized via opioid receptor modulation.

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Authors and Affiliations

  1. E. D. Goldberg Research Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia

    Yu. V. Nesterova, T. N. Povet’yeva, N. I. Suslov, G. N. Zyuz’kov, S. V. Pushkarskii, S. G. Aksinenko, E. E. Schultz, S. S. Kravtsova & A. V. Krapivin

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  1. Yu. V. Nesterova
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  2. T. N. Povet’yeva
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  3. N. I. Suslov
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  4. G. N. Zyuz’kov
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  5. S. V. Pushkarskii
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  6. S. G. Aksinenko
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  7. E. E. Schultz
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  8. S. S. Kravtsova
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  9. A. V. Krapivin
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Correspondence to Yu. V. Nesterova.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 157, No.4, pp. 488-491, April, 2014

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Nesterova, Y.V., Povet’yeva, T.N., Suslov, N.I. et al. Analgesic Activity of Diterpene Alkaloids from Aconitum Baikalensis . Bull Exp Biol Med 157, 488–491 (2014). https://doi.org/10.1007/s10517-014-2598-6

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  • DOI: https://doi.org/10.1007/s10517-014-2598-6

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