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Effect of 3-(3’-Tert-Butyl-4’-Hydroxyphenyl)Propyl Thiosulfonate Sodium on Expression of GSTP1 and NQO1 Genes and Protein Transcription Factors in BALB/c Mouse Liver

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Bulletin of Experimental Biology and Medicine Aims and scope

The study examined dynamics of the effect of novel phenol antioxidant preparation 3-(3’-tertbutyl- 4’-hydroxyphenyl)propyl thiosulfonate sodium (TS-13) on expression of antioxidant protection enzymes genes GSTP1 and NQO1 and on the content of protein transcription factors NF-κB and ATF-2 in mouse liver. Expression of GSTP1 gene decreased significantly on days 4 and 7 after per os administration of TS-13 (100 mg/kg), but increased on post-administration day 14. On days 7 and 14 post-administration, expression of NQO1 gene was significantly increased. On day 7, the hepatic content of the phosphorylated form of ATF-2 and two subunits of nuclear factor NF-κB (p50, p65) decreased significantly.

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Authors and Affiliations

  1. Research Institute of Molecular Biology and Biophysics, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia

    A. B. Shintyapina, O. G. Safronova, V. A. Vavilin & V. V. Lyakhovich

  2. Research Institute of Antioxidant Chemistry, Novosibirsk State Pedagogical University, Novosibirsk, Russia

    N. V. Kandalintseva & A. E. Prosenko

Authors
  1. A. B. Shintyapina
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  2. O. G. Safronova
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  3. V. A. Vavilin
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  4. N. V. Kandalintseva
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  5. A. E. Prosenko
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  6. V. V. Lyakhovich
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Corresponding author

Correspondence to A. B. Shintyapina.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 157, No. 4, pp. 472-474, April, 2014

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Shintyapina, A.B., Safronova, O.G., Vavilin, V.A. et al. Effect of 3-(3’-Tert-Butyl-4’-Hydroxyphenyl)Propyl Thiosulfonate Sodium on Expression of GSTP1 and NQO1 Genes and Protein Transcription Factors in BALB/c Mouse Liver. Bull Exp Biol Med 157, 473–475 (2014). https://doi.org/10.1007/s10517-014-2594-x

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  • DOI: https://doi.org/10.1007/s10517-014-2594-x

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