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Myocardial Serotonin during Ischemia under Conditions of Ischemic Preconditioning

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We studied the dynamics of interstitial serotonin during local myocardial ischemia under conditions of ischemic preconditioning in Wistar rats. Ischemic preconditioning increased serotonin content in the dialysate (p=0.003). During 30-min ischemia, ischemic preconditioning delayed serotonin increase just before the 20th min of ischemia. Ischemic preconditioning promoted short-term increase in the serotonin level in the myocardial interstitium but followed by prolonged ischemia, it delayed the accumulation of serotonin in the myocardial interstitium.

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Authors and Affiliations

  1. Research Institute of Physiology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia

    S. E. Naumenko, T. V. Latysheva & M. A. Gilinskii

Authors
  1. S. E. Naumenko
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  2. T. V. Latysheva
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  3. M. A. Gilinskii
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Corresponding author

Correspondence to S. E. Naumenko.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 157, No. 4, pp. 455-457, April, 2014

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Naumenko, S.E., Latysheva, T.V. & Gilinskii, M.A. Myocardial Serotonin during Ischemia under Conditions of Ischemic Preconditioning. Bull Exp Biol Med 157, 459–461 (2014). https://doi.org/10.1007/s10517-014-2590-1

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  • DOI: https://doi.org/10.1007/s10517-014-2590-1

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