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Role of Neuropeptide Y in Myocardial Contractility of Rats during Early Postnatal Ontogeny

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We studied the effect of neuropeptide Y in concentrations of 10–10-10–6 M on myocardial contractility of rats at the age of 7, 21, and 100 days. Studying the isometric contraction of myocardial strips showed that neuropeptide Y decreases the force of myocardial contraction in 7-day-old rat pups. Exogenous neuropeptide Y produced a biphasic effect in 21-day-old rats, which was manifested in the increase and subsequent decrease in myocardial contractility. Neuropeptide Y had little effect on myocardial contractility of 100-day-old animals.

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Authors and Affiliations

  1. Department of Anatomy, Physiology, and Human Health Protection, Kazan (Volga Region) Federal University, Kazan, Russia

    A. A. Zverev, T. A. Anikina & P. M. Maslyukov

  2. Department of Normal Physiology and Biophysics, Yaroslavl’ State Medical Academy, Yaroslavl’, Russia

    T. L. Zefi rov

Authors
  1. A. A. Zverev
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  2. T. A. Anikina
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  3. P. M. Maslyukov
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  4. T. L. Zefi rov
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Corresponding author

Correspondence to A. A. Zverev.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 157, No. 4, pp. 415-417, April, 2014

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Zverev, A.A., Anikina, T.A., Maslyukov, P.M. et al. Role of Neuropeptide Y in Myocardial Contractility of Rats during Early Postnatal Ontogeny. Bull Exp Biol Med 157, 421–423 (2014). https://doi.org/10.1007/s10517-014-2581-2

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  • DOI: https://doi.org/10.1007/s10517-014-2581-2

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