Optogenetics is a modern nanobiological approaches allowing modulation of the physiological status of electrostimulated cells, including the neurons. The optogenetic approach was used to evaluate the efficiency of synaptic transmission between the neurons in a mixed corticostriatal culture. Synaptic contacts between the cortical and striatal neurons forming in a mixed culture could be modulated by the opticogenetic methods. Studies of the synaptic interactions between the neurons were essential for understanding the disease mechanisms, and therefore, this method seemed to be promising for biomedical studies.
Similar content being viewed by others
References
G. Aston-Jones and K. Deisseroth, Brain Res., 1511, 1-15 (2013).
J. W. Bohland, C. Wu, H. Barbas, et al., PLoS Comput. Biol., 5, No. 3, e1000334 (2009).
E. S. Boyden, F. Zhang, E. Bamberg, et al., Nat. Neurosci., 8, No. 9, 1263-1268 (2005).
L. Fenno, O. Yizhar, and K. Deisseroth, Annu. Rev. Neurosci., 34, 389-412 (2011).
X. Han and E. S. Boyden, PLos sOne, 2, No. 3, e299 (2007).
A. M. Kaufman, A. J. Milnerwood, M. D. Sepers, et al., J. Neurosc., 32, No. 12, 3992-4003 (2012).
B. R. Miller and I. Bezprozvanny, Fut. Neurol., 5, No. 5, 735-756 (2010).
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 157, No. 3, pp. 390-395, March, 2014
Rights and permissions
About this article
Cite this article
Artamonov, D.N., Korzhova, V.V., Vlasova, O.L. et al. Optogenetic Approach to the Studies of Synaptic Transmission. Bull Exp Biol Med 157, 404–407 (2014). https://doi.org/10.1007/s10517-014-2577-y
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10517-014-2577-y