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Suppression of Sulfoconjugation Reduces the Protective Effect of Ortho-Aminoazotoluene on Hepatocarcinogenesis Induced by Diethylnitrosamine in Mice

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The effects of ortho-aminoazotoluene on carcinogenic activity of diethylnitrosamine were studied in CBA and ICR mice. Injection of ortho-aminoazotoluene before and after diethylnitrosamine led to a signifi cant reduction of its anticarcinogenic effect, judging from signifi - cantly lower level of liver tumors. Pentachlorophenol, inhibitor of sulfotransferase (catalyzing the terminal stage of ortho-aminoazotoluene metabolic activity), stimulated its carcinogenic effect on mouse liver. On the other hand, pentachlorophenol reduced the protective effect of ortho-aminoazotoluene on diethylnitrosamine-induced hepatocarcinogenesis in mice. Presumably, the carcinogenic and anticarcinogenic effects of ortho-aminoazotoluene were realized by its initial form or intermediate (non-sulfated) metabolites.

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Authors and Affiliations

  1. Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia

    V. I. Kaledin, S. I. Il’nitskaya & N. A. Popova

  2. Research Institute of Regional Pathology and Pathomorphology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia

    L. A. Bogdanova

Authors
  1. V. I. Kaledin
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  2. S. I. Il’nitskaya
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  3. N. A. Popova
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  4. L. A. Bogdanova
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Correspondence to V. I. Kaledin.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 157, No. 3, pp. 348-351, March, 2014

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Kaledin, V.I., Il’nitskaya, S.I., Popova, N.A. et al. Suppression of Sulfoconjugation Reduces the Protective Effect of Ortho-Aminoazotoluene on Hepatocarcinogenesis Induced by Diethylnitrosamine in Mice. Bull Exp Biol Med 157, 368–370 (2014). https://doi.org/10.1007/s10517-014-2568-z

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  • DOI: https://doi.org/10.1007/s10517-014-2568-z

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