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Effect of 5-HT2A Receptor Antagonists on Blood Flow in the Carotid Vessels upon Elevation of Serotonin Level

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Bulletin of Experimental Biology and Medicine Aims and scope

We studied the ability of predominantly 5-HT2A receptor antagonists to prevent a serotonin-induced change of blood flow in the carotid vessels of rats with experimental serotonin-induced spasm. Ritanserin, ketanserin, and 5-HT2A receptor antagonist RU-476 reduced the effect of serotonin on the blood fl ow velocity in the internal carotid artery by 2.3, 1.7, and 2.6 times, respectively.

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Authors and Affiliations

  1. Volgograd State Medical University, Volgograd, Russia

    D. S. Yakovlev, A. A. Spasov, D. V. Mal’tsev & V. A. Anisimova

  2. Volgograd Medical Research Center, Volgograd, Russia

    D. S. Yakovlev, A. A. Spasov, D. V. Mal’tsev & V. A. Anisimova

Authors
  1. D. S. Yakovlev
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  2. A. A. Spasov
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  3. D. V. Mal’tsev
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  4. V. A. Anisimova
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Corresponding author

Correspondence to D. S. Yakovlev.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 157, No. 3, pp. 328-330, March, 2014

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Yakovlev, D.S., Spasov, A.A., Mal’tsev, D.V. et al. Effect of 5-HT2A Receptor Antagonists on Blood Flow in the Carotid Vessels upon Elevation of Serotonin Level. Bull Exp Biol Med 157, 350–352 (2014). https://doi.org/10.1007/s10517-014-2563-4

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  • DOI: https://doi.org/10.1007/s10517-014-2563-4

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