We studied age-dependent dynamics of some liver parameters in albino rats after antenatal hypoxia. A decrease in body weight, absolute liver weight in newborn and mature rats, and a reduction of relative weight of the liver in mature animals were observed under these conditions. It was found that antenatal hypoxia promotes a decrease in DNA-synthetic activity of hepatocytes, intensifies free radical processes in the liver of newborn rats, and reduces the number of nucleoli in hepatocytes. In mature animals, antenatal hypoxia was followed by a decrease in hepatocyte sizes and area of nucleoli, an increase in the number of binuclear cells relative to mononuclear cells, and a decrease in the number of nucleoli in hepatocyte nuclei. These data can reflect impairment of tissue homeostasis in the liver of mammals exposed to antenatal hypoxia.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 157, No. 3, pp. 301-304, March, 2014
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Pinaeva, O.G., Lebed’ko, O.A., Yakovenko, D.V. et al. Effects of Antenatal Hypoxia on the Parameters of Tissue Homeostasis in the Liver of Albino Rats. Bull Exp Biol Med 157, 327–329 (2014). https://doi.org/10.1007/s10517-014-2557-2
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DOI: https://doi.org/10.1007/s10517-014-2557-2