Skip to main content
SpringerLink
Log in

Phosphate-Dependent Glutaminase Response to Liver Injury and Hyperbaric Oxygenation

  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Activity of phosphate-dependent glutaminase was determined in hepatocytes of white female rats, both in healthy animals and in rats with chronic CCl4-hepatitis on day 3 after liver resection and hyperbaric oxygenation. In healthy animals, activity of phosphate-dependent glutaminase was not altered after hepatic resection, but it was elevated in animals with chronic CCl4-hepatitis. Hyperbaric oxygenation inhibited activity of hepatocytic phosphate-dependent glutaminase in non-operated healthy rats but stimulated it after hepatic resection. In animals with chronic CCl4-hepatitis; hyperbaric oxygenation restricted the stimulating effect of hepatic resection on phosphate-dependent glutaminase activity.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. E. A. Kosenko and Yu. G. Kamiskii, Cellular Mechanisms of Ammonia Toxicity [in Russian]. Moscow (2008).

  2. A. N. Leonov, Hyperoxya. Adaptation. Sanogenesis [in Russian], Voronezh (2006).

  3. P. N. Savilov, Patol. Fiziol. Eksper. Ter., No. 4, 11-13 (2002).

  4. P. N. Savilov, Patol. Fiziol. Eksper. Ter., No. 1, 24-26 (2004).

  5. P. N. Savilov, D. V. Molchanov, and A. A. Alabovskii, Obschaya Reanimatologiia, 6, No. 6, 12-17 (2010).

    Google Scholar 

  6. J. R. Beaton and G. Ozawa, J. Biol. Chem., 214, No. 2, 685-691 (1955).

    CAS  PubMed  Google Scholar 

  7. Advances in Cirrhosis, Hyperammonemia, and Hepatic Encephalopathy, Eds. S. Grisolia, V. Felipo, New York (1997).

  8. E. F. Hartree, Anal. Biochem., 43, No. 2, 422-427 (1972).

    Article  Google Scholar 

  9. D. Häussinger and F. Schliess, Front Biosci., 12, 371-391 (2007).

    Article  PubMed  Google Scholar 

  10. H. P. Himsworth, The Liver and Its Diseases, Oxford (1950).

  11. A. F. Lockwood, J. M. McDonald, R. E. Reinman, et al., J. Clin. Invest., 63, No. 3, 449-460 (1978).

    Article  Google Scholar 

  12. D. Jonson and I. Lardy, Methods Enzymol., 10, 94-96 (1967).

    Article  Google Scholar 

  13. P. N. Savilov and V. N. Yakovlev, Iugosl. Physiol. Pharmacol. Acta, 42, No. 32, 103-114 (2006).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Normal Physiology, N. N. Burdenko Voronezh State Medical Academy, the Ministry of Health of the Russian Federation, Voronezh, Russia

    P. N. Savilov & V. N. Yakovlev

Authors
  1. P. N. Savilov
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. V. N. Yakovlev
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to V. N. Yakovlev.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 157, No. 3, pp. 272-274, March, 2014

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Savilov, P.N., Yakovlev, V.N. Phosphate-Dependent Glutaminase Response to Liver Injury and Hyperbaric Oxygenation. Bull Exp Biol Med 157, 299–301 (2014). https://doi.org/10.1007/s10517-014-2550-9

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10517-014-2550-9

Key Words

Search

Navigation