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A Universal Method for Measuring Functional Activity of Complement in Humans, Laboratory, Domestic, and Agricultural Animals, Amphibians, and Birds

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Bulletin of Experimental Biology and Medicine Aims and scope

A new universal method for measuring activity of the serum complement system in humans, laboratory, domestic, agricultural animals, birds and amphibians is based on automated evaluation of the mortality of ciliate Tetrahymena pyriformis under the effect of the complement system. In contrast to the hemolytic method, measured activity of the complement shows no erroneously high results caused by reactive lysis in febrile patients. The method can be used for studies of the complement system in humans and animals without species-specifi c adaptation.

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Authors and Affiliations

  1. G. N. Gabrichevsky Moscow Research Institute of Epidemiology and Microbiology, Federal Service on Surveillance for Consumer Rights Protection and Human Wellbeing, Moscow, Russia

    O. N. Kuleshina, L. V. Kozlov & E. G. Cheremnykh

Authors
  1. O. N. Kuleshina
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  2. L. V. Kozlov
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  3. E. G. Cheremnykh
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Correspondence to E. G. Cheremnykh.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 157, No. 2, pp. 254-257, February, 2014

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Kuleshina, O.N., Kozlov, L.V. & Cheremnykh, E.G. A Universal Method for Measuring Functional Activity of Complement in Humans, Laboratory, Domestic, and Agricultural Animals, Amphibians, and Birds. Bull Exp Biol Med 157, 285–287 (2014). https://doi.org/10.1007/s10517-014-2546-5

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  • DOI: https://doi.org/10.1007/s10517-014-2546-5

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