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Peptides Regulate Expression of Signaling Molecules in Kidney Cell Cultures during In Vitro Aging

  • Biogerontology
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Bulletin of Experimental Biology and Medicine Aims and scope

We studied the effect of polypeptide complex isolated from calf kidney and short peptides T-31 (AED) and T-35 (EDL) on the expression of signaling molecules, markers of cell renewal (Ki-67, p53), remodeling of the extracellular matrix (MMP-14), and immune response (IL-8) in primary kidney cell cultures during aging. The complex of renal polypeptides and T-31 peptide activate cell renewal processes during aging of the renal epithelium, while gelatinase MMP-14 is the target of T-35 peptide.

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Authors and Affiliations

  1. I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia

    V. Kh. Khavinson

  2. Saint Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, Russia

    V. Kh. Khavinson, N. S. Lin’kova & T. E. Nichik

  3. D. O. Ott Research Institute of Obstetrics and Gynecology, North-West Division of the Russian Academy of Medical Sciences, St. Petersburg, Russia

    V. O. Polyakova, A. O. Durnova & I. M. Kvetnoi

Authors
  1. V. Kh. Khavinson
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  2. N. S. Lin’kova
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  3. V. O. Polyakova
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  4. A. O. Durnova
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  5. T. E. Nichik
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  6. I. M. Kvetnoi
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Corresponding author

Correspondence to N. S. Lin’kova.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 157, No. 2, pp. 227-230, February, 2014

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Khavinson, V.K., Lin’kova, N.S., Polyakova, V.O. et al. Peptides Regulate Expression of Signaling Molecules in Kidney Cell Cultures during In Vitro Aging. Bull Exp Biol Med 157, 261–264 (2014). https://doi.org/10.1007/s10517-014-2540-y

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  • DOI: https://doi.org/10.1007/s10517-014-2540-y

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