The antioxidant effect of an adenosine A1 receptor agonist cyclopentyladenosine was studied on the model of focal cerebral ischemia. Ischemic injury of the brain was accompanied by changes in LPO processes (in the blood and brain tissue) and failure of some factors for antioxidant protection (peroxidase and catalase) that inactivate reactive metabolites. Changes in the ratio between LPO and antioxidant protection were less pronounced after treatment with cyclopentyladenosine.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
G. Z. Sufianova, L. A. Usov, A. A. Sufianov, et al., Eksper. Klin. Farmakol., 64, No. 4, 63-67 (2001).
G. Z. Sufianova, L. A. Usov, A. A. Sufianov, et al., Eksper. Klin. Farmakol., 65, No. 1, 24-26 (2002).
G. Burnstock, B. B. Fredholm, and A. Verkhratsky, Curr. Top. Med. Chem., 11, No. 8, 973-1011 (2011).
J. Fricker, Mol. Med. Today, 6, No. 2, 48 (2000).
H. Karmouty-Quintana, Y. Xia, and M. R. Blackburn, J. Mol. Med. (Berl.), 91, No. 2, 173-181 (2013).
S. Paul, P. H. Elsinga, K. Ishiwata, et al., Curr. Med. Chem., 18, No. 31, 4820-4835 (2011).
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 157, No. 2, pp. 190-193, February, 2014
Rights and permissions
About this article
Cite this article
Sufianova, G.Z., Sufianov, A.A. & Shapkin, A.G. Effect of Cyclopentyladenosine on Lipid Peroxidation during Focal Cerebral Ischemia. Bull Exp Biol Med 157, 228–230 (2014). https://doi.org/10.1007/s10517-014-2531-z
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10517-014-2531-z