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Role of Polymorphic Loci in HLA-Region rs2647012 and rs805288 in the Development of Non-Hodgkin’s Malignant Lymphomas in Western Siberia

  • General Pathology and Pathophysiology
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Bulletin of Experimental Biology and Medicine Aims and scope

The data of genome-wide association analysis suggest that human 6p21.3 chromosomal region (localization of HLA genes) contains polymorphic loci infl uencing the risk of developing non-Hodgkin’s lymphomas. We analyzed association of rs2647012 and rs805288 loci with the risk for non-Hodgkin’s malignant lymphomas in the population of Western Siberia. Allele and genotype frequencies were determined in the group of 298 patients and in the control group including 551 individuals. Subgroups of diffuse large B-cell lymphoma (86 patients) and follicular lymphoma (25 patients) were analyzed separately. An association of rs2647012 А/А genotype with increased risk of the disease (OR = 2.78, p = 0.002) was detected in the subgroup of diffuse large B-cell lymphoma.

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Authors and Affiliations

  1. Institute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia

    A. S. Weiner, M. N. Surovtseva & M. L. Filipenko

  2. Novosibirsk State University, Novosibirsk, Russia

    A. S. Weiner

  3. Novosibirsk State Medical University, Novosibirsk, Russia

    O. V. Berezina, V. S. Ovchinnikov & T. I. Pospelova

  4. Research Institute of Internal Medicine, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia

    E. N. Voropaeva

Authors
  1. A. S. Weiner
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  2. O. V. Berezina
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  3. V. S. Ovchinnikov
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  4. M. N. Surovtseva
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  5. E. N. Voropaeva
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  6. T. I. Pospelova
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  7. M. L. Filipenko
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Corresponding author

Correspondence to A. S. Weiner.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 157, No. 2, pp. 139-142, February, 2014

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Weiner, A.S., Berezina, O.V., Ovchinnikov, V.S. et al. Role of Polymorphic Loci in HLA-Region rs2647012 and rs805288 in the Development of Non-Hodgkin’s Malignant Lymphomas in Western Siberia. Bull Exp Biol Med 157, 180–183 (2014). https://doi.org/10.1007/s10517-014-2520-2

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  • DOI: https://doi.org/10.1007/s10517-014-2520-2

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