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Effects of Nanosized Lithium Carbonate Particles on Intact Muscle Tissue and Tumor Growth

Bulletin of Experimental Biology and Medicine volume 157, pages 89–94 (2014)Cite this article

The effects of nanosized lithium carbonate particles on muscle tissue structure and development of experimental hepatocarcinoma-29 transplanted into the hip were studied in CBA mice. Necrotic changes in all structural components of the muscle were detected after intramuscular injection of nanosized lithium carbonate particles to intact animals. Regeneration of the muscle fi bers after lithium carbonate treatment was associated with a significant increase in macrophage count, number of microvessels, activation of fi broblasts, and complete recovery of the organ structure. Injection of lithium carbonate nanoparticles at the periphery of tumor growth caused tumor cell necrosis, destruction of the vascular bed, and attraction of neutrophils and macrophages to the tumor focus. After the preparation was discontinued, the tumor developed with lesser number of vessels, smaller tumor cells, and lesser deformation of the cell nuclei structure.

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Authors and Affiliations

  1. Research Institute of Clinical and Experimental Lymphology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia

    N. P. Bgatova, Yu. I. Borodin, V. V. Makarova, A. A. Pozhidaeva, L. N. Rachkovskaya & V. I. Konenkov

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  1. N. P. Bgatova
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  2. Yu. I. Borodin
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  3. V. V. Makarova
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  4. A. A. Pozhidaeva
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  5. L. N. Rachkovskaya
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  6. V. I. Konenkov
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Corresponding author

Correspondence to N. P. Bgatova.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 157, No. 1, pp. 102-107, January, 2014

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Bgatova, N.P., Borodin, Y.I., Makarova, V.V. et al. Effects of Nanosized Lithium Carbonate Particles on Intact Muscle Tissue and Tumor Growth. Bull Exp Biol Med 157, 89–94 (2014). https://doi.org/10.1007/s10517-014-2499-8

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  • DOI: https://doi.org/10.1007/s10517-014-2499-8

Keywords

  • nanosized lithium carbonate particles
  • muscle tissue
  • hepatocarcinoma 29 cells