We studied biological characteristics of influenza A(H1N1)pdm09 virus circulating in Siberia during the 2009 pandemic and the post-pandemic period of 2011. BALB/c mice were chosen as the experimental model. Virus titers in the lungs were evaluated on days 1, 3, 6 and blood serum titers on day 15 after infection with different strains. Blood sera of convalescents after influenza of 2010-2011 epidemic season were analyzed. Influenza A(H1N1)pdm09 virus strains isolated during the post-pandemic period of 2011 were characterized by low epidemic activity and virulence in comparison with the strains isolated during 2009 pandemic period, which indicates completion of the pandemic cycle.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 156, No. 11, pp. 620-627, November, 2013
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Prokop’eva, E.A., Kurskaya, O.G., Saifutdinova, S.G. et al. Biological Characteristics of Influenza A(H1N1)pdm09 Virus Circulating in West Siberia During Pandemic and Post-Pandemic Periods. Bull Exp Biol Med 156, 673–679 (2014). https://doi.org/10.1007/s10517-014-2423-2
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DOI: https://doi.org/10.1007/s10517-014-2423-2