We compared anti-inflammatory activity of individual diterpene alkaloids isolated from Aconitum baikalense (napelline, songorine, hypaconitine, mesaconitine, 12-epinapelline N-oxide) under conditions of acute inflammation of different genesis. The tested substances showed high antiexudative activity comparable with that of sodium diclofenac. Unlike nonsteroidal anti-inflammatory drugs, diterpene alkaloids exerted no ulcerogenic effect.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 156, No. 11, pp. 611-615, November, 2013
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Nesterova, Y.V., Povetieva, T.N., Suslov, N.I. et al. Anti-Inflammatory Activity of Diterpene Alkaloids from Aconitum baikalense . Bull Exp Biol Med 156, 665–668 (2014). https://doi.org/10.1007/s10517-014-2421-4
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DOI: https://doi.org/10.1007/s10517-014-2421-4