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Rats of Hypertensive ISIAH Strain are Resistant to the Development of Metabolic Syndrome Induced by High-Fat Diet

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We studied the influence of high-fat diet on the development of metabolic syndrome in rats of hypertensive ISIAH strain and normotensive WAG strain. In contrast to ISIAH rats, highfat diet in WAG rats led visceral obesity, glucose tolerance, and dyslipidemia. DNA-binding activity of the peroxisome proliferator-activated receptor α (PPARα) decreased in the liver of WAG rats and increased in ISIAH rats. Blood levels of TNF-α, IL-6, and corticosterone increased more significantly in WAG rats. Corticosterone content in the adrenal glands was more markedly reduced in WAG rats. High-fat diet had no effect on BP in ISIAH and WAG rats. It was concluded that ISIAH rats can be used as a genetic model in studies of the mechanism of resistance to the metabolic syndrome.

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Authors and Affiliations

  1. Research Institute of Physiology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia

    M. I. Dushkin, M. V. Khrapova, G. G. Kovshik & M. I. Chasovskikh

  2. Research Institute of Therapy, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia

    M. I. Dushkin & M. V. Khrapova

  3. Research Center of Clinical and Experimental Medicine, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia

    V. G. Selyatitskaya & N. A. Palchikova

Authors
  1. M. I. Dushkin
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  2. M. V. Khrapova
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  3. G. G. Kovshik
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  4. M. I. Chasovskikh
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  5. V. G. Selyatitskaya
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  6. N. A. Palchikova
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Corresponding author

Correspondence to M. I. Dushkin.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 156, No. 11, pp. 593-597, November, 2013

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Dushkin, M.I., Khrapova, M.V., Kovshik, G.G. et al. Rats of Hypertensive ISIAH Strain are Resistant to the Development of Metabolic Syndrome Induced by High-Fat Diet. Bull Exp Biol Med 156, 649–653 (2014). https://doi.org/10.1007/s10517-014-2417-0

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  • DOI: https://doi.org/10.1007/s10517-014-2417-0

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