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System of Matrix Metalloproteinases and Cytokine Secretion in Type 2 Diabetes Mellitus and Impaired Carbohydrate Tolerance Associated with Arterial Hypertension

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The study included patients with type 2 diabetes mellitus and impaired carbohydrate tolerance associated with arterial hypertension, patients with arterial hypertension, and healthy volunteers. We evaluated the levels of matrix metalloproteinases 2 and 9 (MMP-2, MMP-9), tissue inhibitor of metalloproteinase type 1 (TIMP-1), glucose, insulin, C-peptide, glycated hemoglobin, and spontaneous and mitogen-activated cytokine secretion (IL-2, IL4, IL-6, IL-10, IL-17, TNF-α, and IFN-γ). Patients with type 2 diabetes mellitus in combination with arterial hypertension exhibited maximum TIMP-1 levels and TIMP-1/MMP-2, TIMP-1/ MMP-9 ratios as well as enhanced secretion of TNF-α, IL-6, IL-17 and reduced secretion of IL-10 in comparison with healthy individuals. The observed shifts are probably determined the development of systemic hyperinsulinemia in patients suffering from type 2 diabetes mellitus coupled with arterial hypertension.

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Authors and Affiliations

  1. Research Institute of Cardiology, Tomsk, Russia

    I. V. Kologrivova, T. E. Suslova, O. A. Koshel’skaya, I. V. Vinnitskaya & O. A. Trubacheva

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  1. I. V. Kologrivova
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  2. T. E. Suslova
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  3. O. A. Koshel’skaya
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  4. I. V. Vinnitskaya
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  5. O. A. Trubacheva
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Corresponding author

Correspondence to I. V. Kologrivova.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 156, No. 11, pp. 578-581, November, 2013

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Kologrivova, I.V., Suslova, T.E., Koshel’skaya, O.A. et al. System of Matrix Metalloproteinases and Cytokine Secretion in Type 2 Diabetes Mellitus and Impaired Carbohydrate Tolerance Associated with Arterial Hypertension. Bull Exp Biol Med 156, 635–638 (2014). https://doi.org/10.1007/s10517-014-2413-4

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  • DOI: https://doi.org/10.1007/s10517-014-2413-4

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