We studied the effect of Ladasten (30 mg/kg intraperitoneally for 5 days) on the subpopulation composition of T cells in immunocompetent organs of male C57Bl/6 mice during modeling of an anxious-depressive state (chronic zoosocial stress). Stress exposure of animals for 30 days was followed by a decrease in the relative weight of the thymus, increase in the weight of the spleen, reduction of the percentage of T cell populations, and shift in the CD4+/CD8+ ratio toward cytotoxic T cells. Administration of Ladasten had a normalizing effect on the relative weights of study organs and subpopulation composition of T cells in immunocompetent organs, which returned to the control level.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 156, No. 9, pp. 310-312, September, 2013
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Tallerova, A.V., Kovalenko, L.P., Kuznetsova, O.S. et al. Correcting Effect of Ladasten on Variations in the Subpopulation Composition of T Lymphocytes in C57Bl/6 Mice on the Experimental Model of an Anxious-Depressive State. Bull Exp Biol Med 156, 335–337 (2014). https://doi.org/10.1007/s10517-014-2343-1
- T cells
- anxious-depressive state