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Correcting Effect of Ladasten on Variations in the Subpopulation Composition of T Lymphocytes in C57Bl/6 Mice on the Experimental Model of an Anxious-Depressive State

Bulletin of Experimental Biology and Medicine volume 156, pages 335–337 (2014)Cite this article

We studied the effect of Ladasten (30 mg/kg intraperitoneally for 5 days) on the subpopulation composition of T cells in immunocompetent organs of male C57Bl/6 mice during modeling of an anxious-depressive state (chronic zoosocial stress). Stress exposure of animals for 30 days was followed by a decrease in the relative weight of the thymus, increase in the weight of the spleen, reduction of the percentage of T cell populations, and shift in the CD4+/CD8+ ratio toward cytotoxic T cells. Administration of Ladasten had a normalizing effect on the relative weights of study organs and subpopulation composition of T cells in immunocompetent organs, which returned to the control level.

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Authors and Affiliations

  1. V. V. Zakusov Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia

    A. V. Tallerova, L. P. Kovalenko, O. S. Kuznetsova, A. D. Durnev & S. B. Seredenin

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  1. A. V. Tallerova
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  2. L. P. Kovalenko
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  3. O. S. Kuznetsova
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  4. A. D. Durnev
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  5. S. B. Seredenin
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Correspondence to A. V. Tallerova.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 156, No. 9, pp. 310-312, September, 2013

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Tallerova, A.V., Kovalenko, L.P., Kuznetsova, O.S. et al. Correcting Effect of Ladasten on Variations in the Subpopulation Composition of T Lymphocytes in C57Bl/6 Mice on the Experimental Model of an Anxious-Depressive State. Bull Exp Biol Med 156, 335–337 (2014). https://doi.org/10.1007/s10517-014-2343-1

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  • DOI: https://doi.org/10.1007/s10517-014-2343-1

Key Words

  • Ladasten
  • T cells
  • anxious-depressive state