We analyzed mutagenic and mitosis-modifying effects of silver nanoparticles (Allium test). Chromosome aberrations and laggings and micronuclei were simultaneously registered in the same sample. Mitotic and phase indexes were calculated. No mutagenic effects were detected after treatment with silver nanoparticles in doses of 1.0, 2.5, 5.0, and 50 mg/liter. Silver nanoparticles in a concentration of 50 mg/liter significantly increased the mitotic index. Nanoparticles in a dose of 5 mg/liter induced slight, but significant increase in mitotic index, but did not affect the ratio of phase indexes. Exposure to silver nanoparticles in concentrations of 1.0 and 2.5 mg/liter was not followed by modification of mitosis.
Similar content being viewed by others
References
D. S. Jumagazieva, G. N. Maslyakova, L. V. Suleymanova, et al., Bull. Exp. Biol. Med., 151, No. 6, 731-733 (2011).
B. S. Kibrik, A. V. Zakharov, and G. N. Kreitsberg, Nanocomposite “Isoniasidi + Ag” in the Treatment of Tuberculosis in vitro, in vivo [in Russian], Yaroslavl’ (2010).
B. S. Kibrik, A. V. Pavlov, A. V. Zakharov, and G. N. Kreitsberg, Eksp. Klin. Farmakol., 74, No. 4, 24-26 (2011).
B. S. Kibrik, V. M. Lobanovskii, A. V. Zakharov, et al., Patent RF No. 2403050, Combined medicinal preparation containing silver nanoparticles with antituberculous effects, Byull. No. 31, November 10, 2010.
D. S. Pesnya, A. V. Romanovskii, I. M. Prokhorova, et al., Biomed Radioelektron., No. 4, 34-45 (2011).
V. A. Tarasov, Mutagens and Carcinogens in the Environment. New Approaches for Estimation of Health Risks [in Russian], St. Petersburg (1998), 15-30.
P. V. AshaRani, G. Low Kah Mun, M. P. Hande, and S. Valiyaveettil, ACS Nano., 3, No. 2, 279-290 (2009).
A. Barberio, J. C. Vottolini, and M. L. S. Mello, Ecotoxicology., 20, No. 4, 927-935 (2011).
S. Cotelle, J. F. Masfaraud, and J. F. Férard, Mutat. Res., 426, No. 2, 167-171 (1999).
M. Ghosh, A. Chakraborty, M. Bandyopadhyay, and A. Mukherjee, J. Hazard. Mater., 197, 327-336 (2011).
K. Klaňcnik, D. Drobne, J. Valant, and J. Dolenc Koce, Ecotoxiol. Environ. Saf., 74, No. 1, 85-92 (2011).
K. K. Panda, V. M. Achary, R. Krishnaveni, et al., Toxicol. In Vitro., 25, No. 5, 1097-1105 (2011).
D. S. Pesnya and A. V. Romanovsky, Mutat. Res., 750, 27-33 (2013).
A. H. Siddiqui, S. Tabrez, and M. Ahmad, Environ. Monit. Assess., 179, Nos. 1-4, 241-253 (2011).
N. Singh, B. Manshian, G. J. Jenkins, et al., Biomaterials, 30, Nos. 23-24, 3891-3941 (2009).
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 156, No. 8, pp. 223-228, August, 2013
Rights and permissions
About this article
Cite this article
Prokhorova, I.M., Kibrik, B.S., Pavlov, A.V. et al. Estimation of Mutagenic Effect and Modifications of Mitosis by Silver Nanoparticles. Bull Exp Biol Med 156, 255–259 (2013). https://doi.org/10.1007/s10517-013-2325-8
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10517-013-2325-8