The incidence of breast tumor in inbred C3H-A mice (virgin female) from hyperthyroid, hypothyroid, and euthyroid control groups at week 44 of the experiment was 86.67, 30, and 62.5%, respectively. The percentage of metastatic lymph nodes in these groups was 65.9 ± 16.7, 35.9 ± 5.9, and 53.9 ± 7.2%, respectively (p < 0.005). It was shown that hyperthyroidism was associated with increased incidence and aggressiveness of breast tumor, while hypothyroidism was associated with lower incidence of breast tumor in comparison with the control.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 156, No. 8, pp. 212-214, August, 2013
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Glushakov, R.I., Proshin, S.N. & Tapil’skaya, N.I. The Incidence of Breast Tumor during Experimental Hyperthyroidism. Bull Exp Biol Med 156, 245–247 (2013). https://doi.org/10.1007/s10517-013-2322-y
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DOI: https://doi.org/10.1007/s10517-013-2322-y