Clinical morphological efficiency of local application of a new biopolymeric film was studied. The film was based on methylcellulose derivatives and contained shikonin (preparation of plant origin) and its esters isolated from Lithospermum erythrorhizon L. cell culture. Combined therapy of 30 patients (34-72 years) with erosive ulcerative lichen planus and leukoplakia of the buccal mucosa was carried out. Local application of the new drug led to more rapid pain relief, epithelialization of the inflammatory destructive foci in the buccal mucosa, and reduced the intensity of morphological signs of lesions in the studied patient population.
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V. B. Akinfieva, S. D. Arutyunov, E. E. Bragina, and Yu. N. Perlamutrov, Dental Forum, 4, No. 17, 24–29 (2005).
S. D. Arutyunov, V. B. Akinfieva, and Yu. N. Perlamutrov, Ros. Stomatol. Zh., No. 2, 17–20 (2007).
E. B. Zagorodnyaya, G. I. Oskol’skii, A. Ya. Basharov, and L. M. Nepomnyashchikh, Sib. Med. Zh. (Tomsk), 27, No. 2, 82–86 (2012).
E. B. Zagorodnyaya, G. I. Oskol’skii, A. Ya. Basharov, and A. V. Shcheglov, Dalnevostochn. Med. Zh., No. 1, 84–86 (2012).
E. B. Zagorodnyaya, G. I. Oskol’skii, E. L. Lushnikova, et al., Fundament. Issled., No. 10, Pt. 3, 495–497 (2011).
T. B. Karyagina, V. G. Arzumanyan, T. V. Timchenko, and D. I. Bairamashvili, Khim.-Farm. Zh., 35, No. 8, 30–31 (2001).
S. L. Litvinov, Ros. Zh. Kozh. Ven. Bol., No. 3, 44–46 (2003).
L. M. Lukinykh and N. V. Tiunova, Maestro Stomatol., No. 4, 79–81 (2009).
Yu. N. Zhuravlyov, S. A. Fedoreev, V. P. Bulgakov, et al., Patent of Russia No. 2141840. Shikonin Oil – Anti-Inflammatory and Antibacterial Drug, Byull. No. 33, 27.11.1999 (1999).
L. V. Petrova, N. E. Kushlinskii, and Ya. L. Makarov, Vestn. Dermatol. Venereol., No. 4, 68–69 (2004).
O. P. Samoilova, V. D. Molokov, S. I. Noskov, and N. M. Rudykh, Sib. Med. Zh. (Irkutsk), 72, No. 5, 44–46 (2007).
S. S. Timoshin, M. Yu. Fleishman, E. B. Zagorodnyaya, et al., Bull. Exp. Biol. Med., 154, No. 2, 283–286 (2012).
E. L. Epel’dimova and O. F. Rabinovich, Stomatologiya, No. 3, 58–63 (2005).
V. P. Papageorgiou, A. N. Assimopoulou, and A. C. Ballis, Curr. Med. Chem., 15, No. 30, 3248–3267 (2008).
Y. Yao and Q. Zhou, Breast Cancer Res. Treat., 121, No. 1, 233–240 (2010).
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 156, No. 8, pp. 199-202, August, 2013
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Zagorodnyaya, E.B., Oskol’skii, G.I., Basharov, A.Y. et al. Biopolymeric Film Containing Bioactive Naphthoquinone (Shikonin) in Combined Therapy of Inflammatory Destructive Lesions in the Buccal Mucosa. Bull Exp Biol Med 156, 232–235 (2013). https://doi.org/10.1007/s10517-013-2318-7
- lichen planus
- buccal mucosa