We studied the role of cAMP- and IKK-2-mediated pathways in the realization of growth potential of mesenchymal progenitor cells in vitro. It had been found that adenylate cyclase inhibitor 2’,5’-dideoxyadenosine had no effect on the proliferation and differentiation of fibroblastic CFU. A decrease in differentiation rate of progenitor cells was observed after the treatment with specific IKK-2 blocker inhibitor-kinase complex.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 156, No. 8, pp. 195-198, August, 2013
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Zyuz’kov, G.N., Zhdanov, V.V., Danilets, M.G. et al. Role of cAMP and IKK-2-Dependent Signaling in the Realization of Growth Potential of Mesenchymal Progenitor Cells. Bull Exp Biol Med 156, 228–231 (2013). https://doi.org/10.1007/s10517-013-2317-8
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DOI: https://doi.org/10.1007/s10517-013-2317-8