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Changes of Protein Profile of Human Urine after Long-Term Orbital Flights

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Bulletin of Experimental Biology and Medicine Aims and scope

We analyzed protein profile of urine samples obtained from 7 Russian cosmonauts (age 35-51 years), participants of space flights on the International Space Station lasting for 169-199 days. Gradient chromatography with linear increase of eluent proportion was carried out in a system consisting of an Agilent 1100 chromatograph (Agilent Technologies Inc.) and a hybrid mass-spectrometer LTQ-FT Ultra (Thermo). The obtained results help to understand changes in the human body induced by space flight factors.

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Authors and Affiliations

  1. State Scientific Center of the Russian Federation Institute of Biomedical Problems, Russian Academy of Sciences, Moscow, Russia

    L. Kh. Pastushkova, O. A. Valeeva, I. M. Larina & I. V. Dobrokhotov

  2. N. M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Moscow, Russia

    A. S. Kononikhin, E. N. Nikolaev & I. A. Popov

  3. Yu. A. Gagarin Research & Test Cosmonaut Trai ning Center, Zvezdnyi Gorodok, Moscow Region, Russia

    V. I. Pochuev & K. S. Kireev

  4. Institute for Energy Problems of Chemical Physics, Russian Academy of Sciences, Moscow, Russia

    A. S. Kononikhin, E. N. Nikolaev & I. A. Popov

Authors
  1. L. Kh. Pastushkova
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  2. O. A. Valeeva
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  3. A. S. Kononikhin
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  4. E. N. Nikolaev
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  5. I. M. Larina
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  6. I. V. Dobrokhotov
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  7. I. A. Popov
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  8. V. I. Pochuev
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  9. K. S. Kireev
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Corresponding author

Correspondence to L. Kh. Pastushkova.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 156, No. 8, pp. 166-170, August, 2013

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Pastushkova, L.K., Valeeva, O.A., Kononikhin, A.S. et al. Changes of Protein Profile of Human Urine after Long-Term Orbital Flights. Bull Exp Biol Med 156, 201–204 (2013). https://doi.org/10.1007/s10517-013-2310-2

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  • DOI: https://doi.org/10.1007/s10517-013-2310-2

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