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Cytochrome P450 4F2 Polymorphism in Patients with Liver Cirrhosis

  • Biophysics and Biochemistry
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Bulletin of Experimental Biology and Medicine Aims and scope

1297C/T polymorphism of CYP4F2 gene was studied in 108 patients with chronic liver diseases. No significant correlation with predisposition to rapid liver cirrhosis was revealed without consideration for cirrhosis etiology (OR = 0.93, 95% CI = 0.28-2.99, p = 0.885). In patients with viral cirrhosis, a tendency to association of 1297T allele genotypes with rapid cirrhosis development was found (OR = 6.0, 95% CI = 0.28-382.64, p = 0.222). At the same time, CYP4F2 1297T allele was associated with mild (Child–Pugh class A-B) cirrhosis (OR = 2.9, p = 0.044).

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Authors and Affiliations

  1. Research Institute for Molecular Biology and Biophysics, Siberian Branch of the Russian Academy of Medical Sciences, Novosibirsk, Russia

    V. A. Vavilin, E. G. Shchepotina, S. I. Makarova, A. V. Kudryashov & V. V. Lyakhovich

  2. Research Institute of Regional Pathology and Pathomorphology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia

    D. L. Nepomnyashchikh, Yu. Yu. Karavaeva, E. V. Vinogradova & Zh. V. Nokhrina

  3. Vektor-Best, Novosibirsk, Russia

    E. G. Shchepotina

Authors
  1. V. A. Vavilin
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  2. D. L. Nepomnyashchikh
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  3. E. G. Shchepotina
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  4. Yu. Yu. Karavaeva
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  5. S. I. Makarova
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  6. E. V. Vinogradova
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  7. A. V. Kudryashov
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  8. Zh. V. Nokhrina
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  9. V. V. Lyakhovich
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Corresponding author

Correspondence to V. A. Vavilin.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 156, No. 8, pp. 144-148, August, 2013

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Vavilin, V.A., Nepomnyashchikh, D.L., Shchepotina, E.G. et al. Cytochrome P450 4F2 Polymorphism in Patients with Liver Cirrhosis. Bull Exp Biol Med 156, 181–184 (2013). https://doi.org/10.1007/s10517-013-2305-z

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  • DOI: https://doi.org/10.1007/s10517-013-2305-z

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